CAS 550999-74-1

Encenicline, HCl salt

Description:

Encenicline, HCl salt, is a chemical compound that acts as a selective agonist for the alpha-7 nicotinic acetylcholine receptor. This compound is primarily investigated for its potential therapeutic applications in cognitive disorders, including Alzheimer's disease and schizophrenia, due to its ability to enhance cholinergic neurotransmission. Encenicline is characterized by its hydrochloride salt form, which improves its solubility and stability in aqueous solutions, making it suitable for pharmaceutical formulations. The compound exhibits a favorable pharmacokinetic profile, including good oral bioavailability and a manageable half-life, which are essential for effective dosing regimens. Additionally, Encenicline has been studied for its safety and tolerability in clinical trials, showing a relatively low incidence of adverse effects compared to other cognitive enhancers. Its mechanism of action involves modulating neurotransmitter release and promoting neuroplasticity, which are critical for cognitive function. Overall, Encenicline, HCl salt represents a promising candidate in the field of neuropharmacology, with ongoing research aimed at fully elucidating its therapeutic potential.

Formula: C₁₆H₁₈Cl₂N₂OS

Synonyms:

• Encenicline, HCl salt
• EVP6124;EVP 6124
• (R)-7-Chloro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride
• Encenicline hydrochloride (EVP-6124)
• EVP-6124 hydrochloride (Encenicline hydrochloride)
• Encenicline hydrochloride
• EVP-6124 (hydrochloride)
• EVP-6124 Hcl

EVP-6124 (hydrochloride)

CAS: 550999-74-1

Formula: C₁₆H₁₈Cl₂N₂OS

Purity: 99%

Molecular weight: 357.2979

Ref: IN-DA00DB64

Encenicline hydrochloride

CAS: 550999-74-1

Encenicline hydrochloride

Purity: ≥98%

Molecular weight: 357.3g/mol

Ref: 54-BUP03965

Encenicline hydrochloride

CAS: 550999-74-1

Encenicline hydrochloride (EVP-6124 hydrochloride) is a new-type partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).

Formula: C₁₆H₁₇ClN₂OS·HCl

Purity: 98.34% - 99.85%

Color and Shape: Solid

Molecular weight: 357.3

Ref: TM-T2285

Encenicline Hydrochloride

Controlled Product

CAS: 550999-74-1

Applications Encenicline hydrochloride is a selective partial agonist of the a7 nicotinic acetylcholine receptor being developed for the cognitive impairment in Alzheimer’s disease and schizophrenia.
References Barbier, A. J., et al.: Clin. Ther., 37,311-324 (2015)

Formula: C₁₆H₁₇ClN₂OS·ClH

Color and Shape: Neat

Molecular weight: 357.298

Ref: TR-E555420

EVP-6124 hydrochloride

CAS: 550999-74-1

EVP-6124 hydrochloride is a pharmaceutical preparation that belongs to the class of amides. It has been shown to modulate the glutamate and acetylcholine neurotransmitter systems in mice. EVP-6124 hydrochloride is a weak agonist at nicotinic acetylcholine receptors with a high affinity for α7 nicotinic acetylcholine receptors in the brain, which may be responsible for its effect on locomotor activity. In addition, this drug has been found to be developable as an anti-convulsant agent. EVP-6124 hydrochloride also inhibits chloride channels and prevents excitotoxicity in mice by acting on chloride channels, but not sodium channels. This drug also causes dehydration in animals due to its ability to inhibit water reabsorption in the kidney.

Formula: C₁₅H₁₆ClNS·ClH

Purity: Min. 95%

Molecular weight: 314.28 g/mol

Ref: 3D-AXA99974