CAS 55102-44-8

N-(2-Chloroethyl)-N′-[2,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)-D-ribofuranosyl]-N-nitrosourea

Description:

N-(2-Chloroethyl)-N′-[2,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)-D-ribofuranosyl]-N-nitrosourea, commonly referred to by its CAS number 55102-44-8, is a synthetic compound that belongs to the class of nitrosoureas, which are known for their alkylating properties. This compound features a complex structure that includes a chloroethyl group, which is responsible for its reactivity, and a ribofuranosyl moiety, which contributes to its biological activity. The presence of the nitrobenzoyl group enhances its potential as an anticancer agent, as nitrosoureas are often utilized in chemotherapy due to their ability to cross-link DNA and inhibit cell division. The compound is typically characterized by its stability under physiological conditions, although it can decompose under certain circumstances, releasing reactive species. Its solubility and stability can vary depending on the formulation and environmental conditions. Overall, this compound is of interest in medicinal chemistry and cancer research, particularly for its potential therapeutic applications.

Formula: C₁₈H₂₁ClN₄O₉

InChI: InChI=1S/C18H21ClN4O9/c1-18(2)31-13-12(9-29-16(24)10-3-5-11(6-4-10)23(27)28)30-15(14(13)32-18)20-17(25)22(21-26)8-7-19/h3-6,12-15H,7-9H2,1-2H3,(H,20,25)/t12-,13-,14-,15?/m1/s1

InChI key: InChIKey=YASNUXZKZNVXIS-CBNXCZCTSA-N

SMILES: N(C(N(CCCl)N=O)=O)C1[C@]2([C@@]([C@@H](COC(=O)C3=CC=C(N(=O)=O)C=C3)O1)(OC(C)(C)O2)[H])[H]

Synonyms:

• (Chloro-2-ethyl)-1-(ribofuranosylisopropylidene-2'-3'-paranitrobenzoate-5')-3-nitrosourea
• (Cloro-2-etil)-1-(ribofuranosilisopropilidene-2',3'-paranitrobenzoato)-3-nitrosourea
• 1-(2-Chloroethyl)-3-(2,3-O-isopropylidene-D-ribofuranosyl)-1-nitrosourea 5'-(p-nitrobenzoate)
• Bofumustina
• Bofumustina [INN-Spanish]
• Bofumustina [Spanish]
• Bofumustine [INN]
• Bofumustinum
• Bofumustinum [INN-Latin]
• Furo(3,4-d)-1,3-dioxole, urea deriv. (9CI)
• Furo[3,4-d]-1,3-dioxole, urea deriv.
• Icig 1105
• N-(2-Chloroethyl)-N′-[2,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)-<span class="text-smallcaps">D</span>-ribofuranosyl]-N-nitrosourea
• N-[(2-chloroethyl)(nitroso)carbamoyl]-2,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)-D-ribofuranosylamine
• N-[(2-chloroethyl)(nitroso)carbamoyl]-2,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)pentofuranosylamine
• Nsc 279194
• Rfcnu
• Unii-6P52D0J76B
• Urea, 1-(2-chloroethyl)-1-nitroso-3-ribofuranosyl-, 5'-(p-nitrobenzoate), 2',3'-cyclicacetal with acetone
• Urea, N-(2-chloroethyl)-N'-(2,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)-D-ribofuranosyl)-N-nitroso-
• Urea, N-(2-chloroethyl)-N′-[2,3-O-(1-methylethylidene)-5-O-(4-nitrobenzoyl)-<span class="text-smallcaps">D</span>-ribofuranosyl]-N-nitroso-
• I.C.I.G. 1105

Bofumustine

Controlled Product

CAS: 55102-44-8

Applications Bofumustine is a nitrosourea containing compound with some antineoplastic property.
References Montero, J., Imbach, J.: C. R. Acad. Sci., 279, 809 (1974);

Formula: C₁₈H₂₁ClN₄O₉

Color and Shape: Neat

Molecular weight: 472.834

Ref: TR-B699845

Bofumustine

CAS: 55102-44-8

Bofumustine is a chloroethyl nitrosourea with anti tumor properties.

Formula: C₁₈H₂₁ClN₄O₉

Color and Shape: Solid

Molecular weight: 472.83

Ref: TM-T26886