CAS 5511-98-8

α-Acetyldigoxin

Description:

α-Acetyldigoxin is a cardiac glycoside derived from digoxin, which is commonly used in the treatment of heart conditions such as atrial fibrillation and heart failure. This compound is characterized by its ability to inhibit the Na+/K+ ATPase enzyme, leading to increased intracellular calcium concentrations and enhanced cardiac contractility. α-Acetyldigoxin has a molecular formula that reflects its complex structure, which includes a steroid nucleus and a sugar moiety. It is typically administered in a pharmaceutical form, and its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are crucial for its therapeutic efficacy. The compound exhibits a relatively high bioavailability and a long half-life, allowing for once-daily dosing in clinical settings. Additionally, α-Acetyldigoxin may have a narrower therapeutic window, necessitating careful monitoring of serum levels to avoid toxicity. Its use is contraindicated in certain conditions, and it may interact with various medications, highlighting the importance of a comprehensive understanding of its pharmacological profile.

Formula: C₄₃H₆₆O₁₅

InChI: InChI=1S/C43H66O15/c1-20-38(49)32(55-23(4)44)18-37(52-20)58-40-22(3)54-36(17-31(40)46)57-39-21(2)53-35(16-30(39)45)56-26-9-11-41(5)25(14-26)7-8-28-29(41)15-33(47)42(6)27(10-12-43(28,42)50)24-13-34(48)51-19-24/h13,20-22,25-33,35-40,45-47,49-50H,7-12,14-19H2,1-6H3/t20-,21-,22-,25-,26+,27-,28-,29+,30+,31+,32+,33-,35+,36+,37+,38-,39-,40-,41+,42+,43+/m1/s1

InChI key: InChIKey=HWKJSYYYURVNQU-DXJNJSHLSA-N

SMILES: O[C@@]12[C@@](C)([C@H](CC1)C=3COC(=O)C3)[C@H](O)C[C@]4([C@]2(CC[C@]5([C@]4(C)CC[C@H](O[C@H]6C[C@H](O)[C@H](O[C@H]7C[C@H](O)[C@H](O[C@H]8C[C@H](OC(C)=O)[C@H](O)[C@@H](C)O8)[C@@H](C)O7)[C@@H](C)O6)C5)[H])[H])[H]

Synonyms:

• (3β,5β,12β)-3-[(O-3-O-Acetyl-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
• 3'''-Acetyldigoxin
• 3-{[3-O-acetyl-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl-(1->6)-2,4-dideoxyhexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
• Acetyl-digoxin-alpha
• Card-20(22)-enolide, 3-((O-3-O-acetyl-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
• Card-20(22)-enolide, 3-[(O-3-O-acetyl-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
• Desglucolanatoside C
• Digorid A
• Digoxigenin + zuckerkette wie bie acetyl-digitoxin A
• Digoxigenin + zuckerkette wie bie acetyl-digitoxin A [German]
• Digoxin, 3'''-acetate
• Digoxin, acetate, alpha-
• Digoxin, acetyl-
• Digoxin, α-acetate
• Digoxin, α-acetyl-
• Lanadigin
• Lanatilin
• Sandolanid
• alpha-Acetyldigoxin
• α-Acetyldigoxin
• (3β,5β,12β)-3-[(O-3-O-Acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide

Digoxin EP Impurity I

CAS: 5511-98-8

Formula: C₄₃H₆₆O₁₅

Color and Shape: White To Off-White Solid

Molecular weight: 822.99

Ref: 4Z-D-758

a-Acetyl digoxin

CAS: 5511-98-8

Formula: C₄₃H₆₆O₁₅

Purity: ≥ 97.0%

Color and Shape: White to off-white or light yellow powder

Molecular weight: 822.98

Ref: 7W-GC4195

a-Acetyl Digoxin

Controlled Product

CAS: 5511-98-8

Applications Digoxin derivative, a cardiotonic glycosides steroid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yoshida, F., et al.: J. Med. Chem., 43, 2575 ( 2000), Turner, J., et al.: Pharm. Res., 21, 68 (2004), Wang, J., et al.: Anal. Chim. Acta, 601, 156 (2007),

Formula: C₄₃H₆₆O₁₅

Color and Shape: Neat

Molecular weight: 822.98

Ref: TR-A173660

a-Acetyl digoxin

CAS: 5511-98-8

a-Acetyl digoxin is a metabolite of digoxin, a type of cardiac glycoside. It is derived from the parent compound digoxin, which is sourced from the leaves of the Digitalis plant. The modification at the acetyl position renders this metabolite with altered biological properties compared to the original compound. a-Acetyl digoxin acts through inhibition of the Na⁺/K⁺-ATPase pump, similar to digoxin, but does so with significantly reduced activity.

Formula: C₄₃H₆₆O₁₅

Purity: Min. 95%

Molecular weight: 822.98 g/mol

Ref: 3D-OA16441

Digoxin EP Impurity I

CAS: 5511-98-8

Formula: C₄₃H₆₆O₁₅

Molecular weight: 823

Ref: ST-EA-CP-D1200008