CAS 5511-98-8: α-Acetyldigoxin

Description:α-Acetyldigoxin is a cardiac glycoside derived from digoxin, which is commonly used in the treatment of heart conditions such as atrial fibrillation and heart failure. This compound is characterized by its ability to inhibit the Na+/K+ ATPase enzyme, leading to increased intracellular calcium concentrations and enhanced cardiac contractility. α-Acetyldigoxin has a molecular formula that reflects its complex structure, which includes a steroid nucleus and a sugar moiety. It is typically administered in a pharmaceutical form, and its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are crucial for its therapeutic efficacy. The compound exhibits a relatively high bioavailability and a long half-life, allowing for once-daily dosing in clinical settings. Additionally, α-Acetyldigoxin may have a narrower therapeutic window, necessitating careful monitoring of serum levels to avoid toxicity. Its use is contraindicated in certain conditions, and it may interact with various medications, highlighting the importance of a comprehensive understanding of its pharmacological profile.

Formula:C₄₃H₆₆O₁₅

InChI:InChI=1S/C43H66O15/c1-20-38(49)32(55-23(4)44)18-37(52-20)58-40-22(3)54-36(17-31(40)46)57-39-21(2)53-35(16-30(39)45)56-26-9-11-41(5)25(14-26)7-8-28-29(41)15-33(47)42(6)27(10-12-43(28,42)50)24-13-34(48)51-19-24/h13,20-22,25-33,35-40,45-47,49-50H,7-12,14-19H2,1-6H3/t20-,21-,22-,25-,26+,27-,28-,29+,30+,31+,32+,33-,35+,36+,37+,38-,39-,40-,41+,42+,43+/m1/s1

InChI key:InChIKey=HWKJSYYYURVNQU-DXJNJSHLSA-N

SMILES:O=C1OCC(=C1)C2CCC3(O)C4CCC5CC(OC6OC(C)C(OC7OC(C)C(OC8OC(C)C(O)C(OC(=O)C)C8)C(O)C7)C(O)C6)CCC5(C)C4CC(O)C23C

Synonyms:
(3β,5β,12β)-3-[(O-3-O-Acetyl-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
3'''-Acetyldigoxin
3-{[3-O-acetyl-2,6-dideoxyhexopyranosyl-(1->4)-2,6-dideoxyhexopyranosyl-(1->6)-2,4-dideoxyhexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide
Acetyl-digoxin-alpha
Card-20(22)-enolide, 3-((O-3-O-acetyl-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-O-2,6-dideoxy-beta-d-ribo-hexopyranosyl-(1.4)-2,6-dideoxy-beta-d-ribo-hexopyranosyl)oxy)-12,14-dihydroxy-, (3beta,5beta,12beta)-
Card-20(22)-enolide, 3-[(O-3-O-acetyl-2,6-dideoxy-β-<span class="text-smallcaps">D</smallcap>-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-<smallcap>D</span>-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
Desglucolanatoside C
Digorid A
Digoxigenin + zuckerkette wie bie acetyl-digitoxin A
Digoxigenin + zuckerkette wie bie acetyl-digitoxin A [German]
See more synonyms
Digoxin, 3'''-acetate
Digoxin, acetate, alpha-
Digoxin, acetyl-
Digoxin, α-acetate
Digoxin, α-acetyl-
Lanadigin
Lanatilin
Sandolanid
alpha-Acetyldigoxin
α-Acetyldigoxin
(3β,5β,12β)-3-[(O-3-O-Acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide
Card-20(22)-enolide, 3-[(O-3-O-acetyl-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-

Found 4 products.

Product data	Purity	Price range	Estimated delivery
Digoxin EP Impurity I REF: 4Z-D-758CAS: 5511-98-8	- - -	1,945.00 €~16,263.00 €	Tue 06 May 25
a-Acetyl digoxin REF: 7W-GC4195CAS: 5511-98-8	≥ 97.0%	To inquire	Tue 06 May 25
a-Acetyl Digoxin REF: TR-A173660CAS: 5511-98-8	- - -	387.00 €~2,624.00 €	Tue 13 May 25
a-Acetyl digoxin REF: 3D-OA16441CAS: 5511-98-8	Min. 95%	984.00 €~3,569.00 €	Tue 10 Jun 25