CAS 552292-08-7

Rolapitant

Description:

Rolapitant is a selective neurokinin-1 (NK1) receptor antagonist primarily used in the prevention of nausea and vomiting associated with chemotherapy. It is characterized by its ability to block the action of substance P, a neuropeptide involved in the emetic response. Rolapitant is typically administered orally and has a long half-life, allowing for once-weekly dosing. Its chemical structure includes a piperidine ring, contributing to its pharmacological properties. The substance is known for its favorable safety profile, with common side effects being mild and manageable. Rolapitant is often used in combination with other antiemetic agents to enhance efficacy in preventing chemotherapy-induced nausea and vomiting. Its development represents a significant advancement in supportive care for cancer patients, improving their quality of life during treatment. As a relatively new agent, ongoing research continues to explore its potential applications and mechanisms of action in various clinical settings.

Formula: C₂₅H₂₆F₆N₂O₂

InChI: InChI=1S/C25H26F6N2O2/c1-16(17-11-19(24(26,27)28)13-20(12-17)25(29,30)31)35-15-23(18-5-3-2-4-6-18)10-9-22(14-32-23)8-7-21(34)33-22/h2-6,11-13,16,32H,7-10,14-15H2,1H3,(H,33,34)/t16-,22-,23-/m1/s1

InChI key: InChIKey=FIVSJYGQAIEMOC-ZGNKEGEESA-N

SMILES: C(O[C@H](C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)[C@]2(CC[C@]3(CN2)NC(=O)CC3)C4=CC=CC=C4

Synonyms:

• Rolapitant
• Varubi
• (5S,8S)-8-[[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one
• 1,7-Diazaspiro[4.5]decan-2-one, 8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-, (5S,8S)-
• (5S,8S)-8-[[[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl]oxy]methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one
• Rolapitant(sch619734)
• SCH619734
• rolapitant,914462-92-3
• Rolapitant HCl
• Rolapitant-d4
• (5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one
• (5S,8S)-8-(((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)methyl)-8-phenyl-1,7-diazaspiro[4.5]decan-2-one hydrochloride.

Rolapitant

CAS: 552292-08-7

Formula: C₂₅H₂₆F₆N₂O₂

Purity: 98%

Molecular weight: 500.4766

Ref: IN-DA00DBMV

Rolapitant

CAS: 552292-08-7

Formula: C₂₅H₂₆F₆N₂O₂

Color and Shape: White To Off-White Solid

Molecular weight: 500.49

Ref: 4Z-R-104001

Rolapitant

CAS: 552292-08-7

Rolapitant

Purity: ≥98%

Molecular weight: 500.48g/mol

Ref: 54-BUP12193

Rolapitant-d4

CAS: 552292-08-7

Formula: C₂₅H₂₂F₆N₂O₂D₄

Molecular weight: 504.51

Ref: 4Z-R-104002

Rolapitant

CAS: 552292-08-7

Rolapitant Hydrochloride is an oral NK1-receptor blocker that prevents nausea and has a fast onset and long half-life.

Formula: C₂₅H₂₆F₆N₂O₂

Purity: 99.86%

Color and Shape: Solid

Molecular weight: 500.48

Ref: TM-T3716