CAS 552325-73-2

(2S)-1-{[5-(3-Methyl-2H-indazol-5-yl)-3-pyridinyl]oxy}-3-phenyl-2-propanamine

Description:

The chemical substance known as (2S)-1-{[5-(3-Methyl-2H-indazol-5-yl)-3-pyridinyl]oxy}-3-phenyl-2-propanamine, with the CAS number 552325-73-2, is a compound that features a chiral center, indicated by the (2S) configuration. This compound contains a propanamine backbone, which is substituted with a phenyl group and a complex side chain that includes a pyridine and an indazole moiety. The presence of the pyridine ring suggests potential interactions with biological targets, making it of interest in medicinal chemistry. The indazole component may contribute to its pharmacological properties, possibly influencing its binding affinity and selectivity. Additionally, the compound's structure indicates it may exhibit specific stereochemical properties that could affect its biological activity. Overall, this substance is likely to be investigated for its potential therapeutic applications, particularly in areas related to neurological or psychiatric disorders, given the structural motifs commonly associated with such activities.

Formula: C₂₂H₂₂N₄O

InChI: InChI=1S/C22H22N4O/c1-15-21-11-17(7-8-22(21)26-25-15)18-10-20(13-24-12-18)27-14-19(23)9-16-5-3-2-4-6-16/h2-8,10-13,19H,9,14,23H2,1H3,(H,25,26)/t19-/m0/s1

SMILES: Cc1c2cc(ccc2n[nH]1)c1cc(cnc1)OC[C@H](Cc1ccccc1)N

Synonyms:

• A-674563
• (S)-1-((5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine hydrochloride
• (S)-1-(5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine
• CS-258
• (alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine A-674563
• Benzeneethanamine, α-[[[5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]-, (αS)-
• A-674563;A 674563; A674563
• (2S)-1-(5-(3-methyl-1H-indazol-5-yl)pyridin-3-yloxy)-3-phenylpropan-2-amine
• (alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine
• A-674563 USP/EP/BP
• A-674563 /A674563

A-674563

CAS: 552325-73-2

Formula: C₂₂H₂₂N₄O

Purity: 99%

Color and Shape: Solid

Molecular weight: 358.4363

Ref: IN-DA00DB4L

(S)-1-((5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine

CAS: 552325-73-2

(S)-1-((5-(3-Methyl-1H-indazol-5-yl)pyridin-3-yl)oxy)-3-phenylpropan-2-amine

Purity: 99%

Molecular weight: 358.44g/mol

Ref: 54-OR1066768

A-674563

CAS: 552325-73-2

A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.

Formula: C₂₂H₂₂N₄O

Purity: 99.21%

Color and Shape: Solid

Molecular weight: 358.44

Ref: TM-T6139

A-674563 (free base)

CAS: 552325-73-2

Ref: 7W-GW8742

A-674563

CAS: 552325-73-2

A-674563 is an inhibitor that binds to the active site of the enzyme pyrazole ring and inhibits its activity. A-674563 has shown biological properties in vivo and in vitro, which may be due to its ability to inhibit cell signaling pathways. This molecule has been shown to inhibit tumor growth in xenograft models, inhibiting fetal bovine hepatocyte-like cells as well as human hepatocyte-like cells in vitro. A-674563 also inhibits the activity of radiation on cancer cells by inducing apoptosis. Structural analysis of this compound supports its binding mode at the pyrazole ring active site.

Formula: C₂₂H₂₂N₄O

Purity: Min. 95%

Molecular weight: 358.44 g/mol

Ref: 3D-CXA32573