CAS 55242-55-2

Propentofylline

Description:

Propentofylline is a xanthine derivative that exhibits properties as a phosphodiesterase inhibitor and adenosine receptor antagonist. It is primarily known for its potential neuroprotective effects and is investigated for its use in treating cognitive disorders and improving blood flow in the brain. The substance is characterized by its ability to enhance cerebral circulation and reduce blood viscosity, which may contribute to its therapeutic effects. Propentofylline is typically administered in oral form and has been studied for its safety and efficacy in various clinical settings. Its chemical structure includes a xanthine core, which is common among other compounds in this class, and it is known to have a relatively low toxicity profile. While it has shown promise in research, its clinical use may vary by region, and it is essential to consider regulatory approvals and guidelines when discussing its application in medical treatments. Overall, propentofylline represents a compound of interest in pharmacology, particularly in the context of neurodegenerative diseases and cognitive enhancement.

Formula: C₁₅H₂₂N₄O₃

InChI: InChI=1/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3

InChI key: InChIKey=RBQOQRRFDPXAGN-UHFFFAOYSA-N

SMILES: C(CC)N1C2=C(N(C)C(=O)N(CCCCC(C)=O)C2=O)N=C1

Synonyms:

• 1-(5-Oxohexyl)-3-methyl-7-propylxanthine
• 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-
• 3,7-Dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione
• 3-Methyl-1-(5-oxohexyl)-7-propylxanthine
• 3-methyl-1-(5-oxohexyl)-7-propyl-3,7-dihydro-1H-purine-2,6-dione
• Albert-285
• Brn 1156290
• Hextol
• Hoe-285
• Hwa 285
• Karsivan
• Propenlotylina
• Propentofylina
• Propentofylina [INN-Spanish]
• Propentofylline [INN:BAN:JAN]
• Propentofyllinum
• Propentofyllinum [INN-Latin]
• Propentophylline
• Unii-5Rta398U4H
• Propentofylline
• Propentofylline
• 5-26-14-00082 (Beilstein Handbook Reference)
• 3-METHYL-1-[5-OXOHEXYL]-7-PROPYL-XANTHINE
• HOE-285：Hextol：Karsivan
• 3-Methyl-1-(5-oxohexyl)-7-propylxanthine, HWA285, 3,7-Dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione
• 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1h-purine-6-dione
• 3-Methyl-1-(5-oxohexyl)-7-propylpurine-2,6-dione

Propentofylline

CAS: 55242-55-2

Propentofylline

Purity: ≥98%

Molecular weight: 306.36g/mol

Ref: 54-BUP02615

Propentofylline

CAS: 55242-55-2

Formula: C₁₅H₂₂N₄O₃

Molecular weight: 306.36

Ref: 7W-GP0800

Propentofylline

CAS: 55242-55-2

Formula: C₁₅H₂₂N₄O₃

Molecular weight: 306.37

Ref: 4Z-P-691

Propentofylline

Controlled Product

CAS: 55242-55-2

Formula: C₁₅H₂₂N₄O₃

Color and Shape: White To Off-White

Molecular weight: 306.36

Ref: TR-P768700

Propentofylline

Controlled Product

CAS: 55242-55-2

Propentofylline is a drug that has been shown to be neuroprotective in experimental models of stroke and brain injury. It inhibits glutamate-induced neuronal death by inhibiting the activation of nuclear DNA, leading to suppression of nuclear factor kappa B (NF-κB) and toll-like receptor (TLR) signaling pathways. It also decreases activity in cyclic nucleotide phosphodiesterases, which are enzymes involved in the regulation of cellular energy metabolism. Propentofylline increases microglial motility, which may be due to its ability to increase neurotrophic factors such as basic fibroblast growth factor and nerve growth factor.

Formula: C₁₅H₂₂N₄O₃

Purity: Min. 95%

Molecular weight: 306.36 g/mol

Ref: 3D-FP27197

Propentofylline

CAS: 55242-55-2

Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.

Formula: C₁₅H₂₂N₄O₃

Purity: 99.76% - 99.86%

Color and Shape: Off-White Solid

Molecular weight: 306.36

Ref: TM-T19812