CAS 55297-96-6

Tiamulin fumarate

Description:

Tiamulin fumarate is a synthetic antibiotic belonging to the pleuromutilin class, primarily used in veterinary medicine for the treatment of bacterial infections in livestock, particularly in pigs and poultry. It is effective against a range of Gram-positive bacteria and some Gram-negative bacteria, making it valuable in managing respiratory diseases and other infections in animals. The compound is characterized by its ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby disrupting the translation process. Tiamulin fumarate is typically administered orally or via injection, and its pharmacokinetics can vary based on the route of administration and the species treated. The fumarate salt form enhances its stability and solubility, facilitating its use in formulations. While generally considered safe for animals, it is important to adhere to withdrawal periods before slaughter to minimize residues in meat products. As with any antibiotic, the potential for resistance development necessitates careful use and adherence to veterinary guidelines.

Formula:C₂₈H₄₇NO₄S·C₄H₄O₄

InChI:InChI=1/C28H47NO4S.C4H4O4/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28;5-3(6)1-2-4(7)8/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t19?,20-,22+,24-,25-,26+,27-,28-;/m0./s1

InChI key:YXQXDXAHCSEVSD-GCYNEOGWSA-N

SMILES:C[C@@H]1[C@]23[C@]([C@](C)([C@H](OC(CSCCN(CC)CC)=O)C[C@](C=C)(C)[C@H]1O)[C@H](C)CC2)(C(=O)CC3)[H].C(=C/C(O)=O)\C(O)=O

Synonyms:

((2-(Diethylamino)Ethyl)Thio)Acetic Acid 8-Ester With (3As,4R,5S,6S,8R,9R,9Ar,10R)-Octahydro-5,8-Dihydroxy-4,6,9,10-Tetramethyl-6-Vinyl-3A,9-Propano-3Ah-Cyclopentacycloocten-1(4H)-One Fumarate
(3aS,4R,5S,6S,8R,9R,9aR)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl {[2-(diethylamino)ethyl]sulfanyl}acetate (2E)-but-2-enedioate (salt)
(4R,5S,6S,8R,9aS,10R)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl {[2-(diethylamino)ethyl]sulfanyl}acetate (2E)-but-2-enedioate (salt)
,10-Tetramethyl-1-Oxo-3-Alpha,9-Propano-3-Alpha-H-Cyclopentacycloocten-8-Yles
14-Deoxy-14-((2-Diethylaminoethyl)-Mercaptoacetoxy)-Mutilinhydrogenfumarate
14-Deoxy-14-[(2-diethylaminoethyl)-mercaptoacetoxy]mutilin hydrogen fumarate
14-Desossi-14-((2-Dietilaminoetil)Mercapto-Acetossi)Mutilinidrogenofumarato
3a,9-Propano-3aH-cyclopentacyclooctene, acetic acid deriv.
81723Hfu
Acetic acid, 2-[[2-(diethylamino)ethyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, (2E)-2-butenedioate (1:1)
Acetic acid, [[2-(diethylamino)ethyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, (2E)-2-butenedioate (1:1) (salt)
Acetic acid, [[2-(diethylamino)ethyl]thio]-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, [3aS-(3aα,4β,5α,6α,8β,9α,9aβ,10S*)]-, (E)-2-butenedioate (1:1) (salt)
Denagard
Dynamutilin
Sandoz 81723hfu
Sandoz81723Hfu
Sq 22947
Thiamutilin fumarate
Tiamulin Fumarate
Tiamulin hydrogen fumarate
Tiamuline Hydrogen Fumarate
Tiamupharm
Tiamutin
Tiavet
Vievitin
TIAMULIN FUMERATE
Acetic acid, 2-(diethylamino)ethylthio-, (3aS,4R,5S,6S,8R,9S,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, (2E)-2-butenedioate (1:1) (salt)
STAMULIN
thiamutilinfumarate
[[2-(Diethylamino)ethyl]thio]-acetic acid 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester (E)-2-butenedioate
TIAMULIN FUMARATE VETRANAL, 100 MG
sq22947
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CAS 55297-96-6

Tiamulin fumarate

Tiamulin fumarate

Ref: 3D-FD28262