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CAS 5534-18-9

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Beclomethasone 17-monopropionate

Description:
Beclomethasone 17-monopropionate is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties. It is a derivative of beclomethasone, characterized by the presence of a propionate ester at the 17-position, which enhances its potency and bioavailability when administered topically or via inhalation. This compound is often utilized in the treatment of various respiratory conditions, such as asthma and allergic rhinitis, as well as in dermatological formulations for inflammatory skin disorders. Beclomethasone 17-monopropionate exhibits a high affinity for glucocorticoid receptors, leading to the modulation of gene expression involved in inflammation and immune responses. Its pharmacokinetics indicate a rapid onset of action, with a relatively short half-life, necessitating multiple doses for sustained therapeutic effects. The substance is typically formulated in aerosol or topical preparations, allowing for targeted delivery and minimizing systemic side effects. Safety profiles indicate that, when used as directed, it has a favorable risk-benefit ratio, although potential side effects may include local irritation or, with prolonged use, systemic effects associated with corticosteroids.
Formula:C25H33ClO6
InChI:InChI=1S/C25H33ClO6/c1-5-21(31)32-25(20(30)13-27)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,26)19(29)12-23(18,25)4/h8-9,11,14,17-19,27,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1
InChI key:InChIKey=OHYGPBKGZGRQKT-XGQKBEPLSA-N
SMILES:O(C(CC)=O)[C@@]1(C(CO)=O)[C@]2(C)[C@@](C[C@@H]1C)([C@]3([C@](Cl)([C@@H](O)C2)[C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H]
Synonyms:
  • (11Beta,16Beta)-9-Chloro-11,21-Dihydroxy-16-Methyl-3,20-Dioxopregna-1,4-Dien-17-Yl Propanoate
  • (11β,16β)-9-Chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)pregna-1,4-diene-3,20-dione
  • 9-Chloro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
  • Beclomethasone 17-monopropionate
  • Beclomethasone 17-propionate
  • Pregna-1,4-diene-3,20-dione, 9-chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-, (11beta,16beta)-
  • Pregna-1,4-diene-3,20-dione, 9-chloro-11,21-dihydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-
  • Pregna-1,4-diene-3,20-dione, 9-chloro-11β,17,21-trihydroxy-16β-methyl-, 17-propionate
  • Pregna-1,4-diene-3,2O-dione, 9-chloro-11β,17,21-trihydroxy-16β-methyl-, 17-propionate
  • Unii-5Bga9Fd55H
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Found 16 products.