CAS 5536-17-4

Vidarabine

Description:

Vidarabine, also known as adenine arabinoside, is an antiviral nucleoside analog primarily used in the treatment of viral infections, particularly herpes simplex virus and varicella-zoster virus. It is characterized by its structure, which includes an arabinose sugar moiety linked to an adenine base, distinguishing it from natural nucleosides. Vidarabine exhibits its antiviral activity by inhibiting viral DNA synthesis, thereby preventing the replication of the virus. The compound is typically administered intravenously due to its poor oral bioavailability. It has a relatively short half-life, necessitating careful dosing and monitoring during treatment. Vidarabine can cause side effects, including neurotoxicity and hematological issues, which require consideration in clinical settings. Its use has declined with the advent of more effective antiviral agents, but it remains a significant compound in the study of antiviral therapies. As a chemical entity, Vidarabine is classified under the category of purine nucleosides and has a specific CAS number, 5536-17-4, which is used for its identification in chemical databases.

Formula: C₁₀H₁₃N₅O₄

InChI: InChI=1/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(16)1-19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7+,10-/m1/s1

InChI key: InChIKey=OIRDTQYFTABQOQ-UHTZMRCNSA-N

SMILES: O[C@@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](CO)[C@H]1O

Synonyms:

• 6-Amino-9-beta-D-arabinofuranosylpurine
• 6-Amino-9-β-<span class="text-smallcaps">D</span>-arabinofuranosylpurine
• 6-Amino-9-β-D-arabinofuranosylpurine
• 9-(beta-D-Arabinofuranosyl)-9H-purin-6-amine
• 9-(beta-D-glycero-Pentofuranosyl)-9H-purin-6-amine
• 9-Arabinosyladenine
• 9-beta-D-Arabinofuranosyladenine
• 9-β-<span class="text-smallcaps">D</span>-Arabinoadenosine
• 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosyl-9H-purin-6-amine
• 9-β-<span class="text-smallcaps">D</span>-Arabinofuranosyladenine
• 9-β-<span class="text-smallcaps">D</span>-Arabinosyladenine
• 9-β-D-Arabinoadenosine
• 9-β-D-Arabinofuranosyl-9H-purin-6-amine
• 9-β-D-Arabinofuranosyl-adenine
• 9-β-D-Arabinofuranosyladenine
• 9-β-D-Arabinosyladenine
• 9-β-D-arabinopyranosyl-9H-purin-6-amine
• 9H-Purin-6-amine, 9-beta-D-arabinofuranosyl-
• 9H-Purin-6-amine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• 9H-Purin-6-amine, 9-β-D-arabinofuranosyl-
• 9H-purin-6-amine, 9-beta-D-glycero-pentofuranosyl-
• Adenine 9-β-<span class="text-smallcaps">D</span>-arabinofuranoside
• Adenine 9-β-D-arabinofuranoside
• Adenine arabinoside
• Adenine β-<span class="text-smallcaps">D</span>-arabinofuranoside
• Adenine β-D-arabinofuranoside
• Adenine, 9-beta-D-arabinofuranosyl-
• Adenine, 9-β-<span class="text-smallcaps">D</span>-arabinofuranosyl-
• Adenine, 9-β-D-arabinofuranosyl-
• Ara-A
• Araadenosine
• Arabinosyladenine
• Arasena-A
• Ci-673
• Nqz-071
• Nsc 247519
• Nsc 404241
• Spongoadenosine
• Vidarabin
• Vidarabina
• Vidarabine anhydrous
• Vira-A
• β-<span class="text-smallcaps">D</span>-Arabinofuranosyladenine
• β-<span class="text-smallcaps">D</span>-Arabinosyladenine
• β-Ara-A
• β-D-Arabinofuranosyladenine
• β-D-Arabinosyladenine
• beta-d-arabinosyladenine
• ADENINE-BETA-D-ARABINOFURANOSIDE
• 9-beta-d-arabinofuranosyl-adenin
• 9-beta-d-arabinofuranosyl-9h-purin-6-amin
• VIDARABINE
• adeninearabinoside
• beta-ara-a
• ci673
• ADENINE-9-BETA-D-ARABINOFURANOSIDE
• ARABINOSYL-ADENINE
• 2'-ARAADENOSINE

Vidarabine

CAS: 5536-17-4

Formula: C₁₀H₁₃N₅O₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 267.25

Ref: 3B-V0175

Vidarabine Monohydrate

CAS: 24356-66-9, 5536-17-4

Formula: C₁₀H₁₃N₅O₄·H₂O

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 285.27

Ref: 3B-V0098

9-β-D-Arabinofuranosyladenine, 99%

CAS: 5536-17-4

Vidarabine is a neurotransmitter that acts as the preferred endogenous agonist at all adenosine receptor subtypes. Vidarabine is an inhibitor of A cyclase and DNA Polymerase. Used to study the roles of AMP-activated protein kinase (AMPK) in cell signaling. Cell-permeable adenylate cyclase inhibitor;

Formula: C₁₀H₁₃N₅O₄

Purity: 99%

Molecular weight: 267.24

Ref: 02-J65076

Vidarabine

CAS: 5536-17-4

Vidarabine is a nucleoside antibiotic from Streptomyces with antiviral properties, effective against herpes and other DNA viruses.

Formula: C₁₀H₁₃N₅O₄

Purity: 99.85%

Color and Shape: White To Off-White Crystalline Powder

Molecular weight: 267.24

Ref: TM-T1506

Adenine 9-β-D-arabinofuranoside

CAS: 5536-17-4

Formula: C₁₀H₁₃N₅O₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 267.2413

Ref: IN-DA0034FO

Adenine 9-β-D-arabinofuranoside

CAS: 5536-17-4

Adenine 9-β-D-arabinofuranoside

Purity: 99%

Molecular weight: 267.24g/mol

Ref: 54-OR1012219

Vidarabine

CAS: 5536-17-4

Vidarabine

Purity: ≥98%

Molecular weight: 267.24g/mol

Ref: 54-BUP14712

Adenine 9-β-D-arabinofuranoside

CAS: 5536-17-4

Formula: C₁₀H₁₃N₅O₄

Purity: ≥ 99.0%

Color and Shape: White to off-white powder

Molecular weight: 267.24

Ref: 7W-GA0167

9-(b-D-Arabinofuranosyl)adenine

CAS: 5536-17-4

9-(b-D-Arabinofuranosyl)adenine is a nucleoside that is used as an antiviral agent. It binds to viral RNA and inhibits viral replication. 9-(b-D-Arabinofuranosyl)adenine has been shown to have potent side-effect profiles, including myocardial infarct, neuronal death, and immunological reactions. These effects are due to its ability to inhibit the synthesis of guanine nucleotides in the heart and brain cells, which are essential for energy production and neurotransmitter release respectively. 9-(b-D-Arabinofuranosyl)adenine also binds to toll-like receptors (TLRs), which are proteins found on the surface of cells that recognize invading microbes or foreign substances. This binding leads to activation of immune response pathways.

Formula: C₁₀H₁₃N₅O₄

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 267.24 g/mol

Ref: 3D-NA06007

(2R,3S,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

CAS: 5536-17-4

Formula: C₁₀H₁₃N₅O₄

Purity: 95%

Color and Shape: Crystalline Powder,Powder

Molecular weight: 267.245

Ref: 10-F091487

Vidarabine

Controlled Product

CAS: 5536-17-4

Applications Vidarabine, is an antiviral drug which is active against herpes simplex and varicella zoster viruses.
References Sneader, W., et al.: Drug Discovery, 258 (2005); Lee, W. W., et al.: J. Am. Chem. Soc., 82, 2648 (1960);

Formula: C₁₀H₁₃N₅O₄

Color and Shape: Neat

Molecular weight: 267.24

Ref: TR-V305030