CAS 553644-01-2

Abz-Ser-Pro-3-Nitro-Tyr-Oh

Description:

Abz-Ser-Pro-3-Nitro-Tyr-OH, with the CAS number 553644-01-2, is a synthetic peptide that features a sequence of amino acids, including 3-nitrotyrosine, which is a modified form of the amino acid tyrosine. This compound is characterized by its incorporation of an amino acid sequence that typically includes an amino group (Abz), serine (Ser), proline (Pro), and a nitro group on the tyrosine residue, which can influence its biochemical properties and interactions. The presence of the nitro group can enhance the compound's reactivity and may affect its biological activity, making it of interest in various research fields, including biochemistry and pharmacology. Peptides like Abz-Ser-Pro-3-Nitro-Tyr-OH are often studied for their roles in signaling pathways, enzyme activity, and potential therapeutic applications. Additionally, the stability, solubility, and overall behavior of this compound in biological systems can be influenced by its specific amino acid composition and modifications.

Formula: C₂₄H₂₇N₅O₉

InChI: InChI=1S/C24H27N5O9/c25-15-5-2-1-4-14(15)21(32)27-17(12-30)23(34)28-9-3-6-18(28)22(33)26-16(24(35)36)10-13-7-8-20(31)19(11-13)29(37)38/h1-2,4-5,7-8,11,16-18,30-31H,3,6,9-10,12,25H2,(H,26,33)(H,27,32)(H,35,36)/t16-,17-,18-/m0/s1

InChI key: InChIKey=RQLMBNGGUMATLG-BZSNNMDCSA-N

SMILES: C([C@@H](NC(=O)C1=C(N)C=CC=C1)CO)(=O)N2[C@H](C(N[C@@H](CC3=CC(N(=O)=O)=C(O)C=C3)C(O)=O)=O)CCC2

Synonyms:

• L-Tyrosine, N-(2-aminobenzoyl)-L-seryl-L-prolyl-3-nitro-
• Abz-SP-3-nitro-Tyr-OH
• L-Tyrosine, N-(2-aminobenzoyl)-L-seryl-L-prolyl-3-nitro- (9CI)
• ABZ-SER-PRO-3-NITRO-TYR-OH

Abz-Ser-Pro-3-nitro-Tyr-OH

CAS: 553644-01-2

Selective substrate for angiotensin-converting enzyme 2 (ACE2), an ACE homolog which differs in its specificity and physiological role from ACE. The internally quenched fluorescent (FRET) substrate is potentially useful in applications such as high-throughput screening of ACE2 inhibitors (Km = 23 µM, kcat/Km = 3.5 · 10⁴ M⁻¹s⁻¹).

Formula: C₂₄H₂₇N₅O₉

Purity: 98.4%

Color and Shape: Yellow Lyophilisate

Molecular weight: 529.51

Ref: 01-4050533

Abz-Ser-Pro-3-nitro-Tyr

CAS: 553644-01-2

Abz-Ser-Pro-3-nitro-Tyr is the substrate of ACE2 (angiotensin-converting enzyme-2) [1] .

Formula: C₂₄H₂₇N₅O₉

Color and Shape: Solid

Molecular weight: 529.5

Ref: TM-T76605

Abz-Ser-Pro-3-nitro-Tyr-OH

CAS: 553644-01-2

Abz-Ser-Pro-3-nitro-Tyr-OH is a chromophobe peptide that is expressed in renal cell carcinomas. It is a potent inhibitor of all three major classes of proteases: serine, cysteine and aspartyl proteases. Abz-Ser-Pro-3-nitro-Tyr-OH inhibits the activity of peptidases, which are enzymes involved in protein degradation and turnover. Abz has been shown to inhibit the activity of intrarenal proteolytic enzymes, including endopeptidase, metallopeptidase and aminopeptidase activities. Abz also has been shown to inhibit the expression of markers on the surface of kidney cells and to reduce renal cell proliferation.

Formula: C₂₄H₂₇N₅O₉

Purity: Min. 95%

Molecular weight: 529.5 g/mol

Ref: 3D-FA110992