CAS 55486-09-4

5-Methyl-2′-O-methyluridine

Description:

5-Methyl-2′-O-methyluridine is a modified nucleoside, specifically a derivative of uridine, which is one of the four nucleosides that make up RNA. This compound features a methyl group at the 5-position of the uracil base and a methoxy group at the 2′ position of the ribose sugar. These modifications can influence the stability, recognition, and function of RNA molecules in which they are incorporated. 5-Methyl-2′-O-methyluridine is known for its role in enhancing the stability of RNA and can be involved in various biological processes, including gene expression and regulation. It is often studied in the context of RNA therapeutics and vaccine development, particularly for its potential to improve the efficacy of mRNA-based technologies. The presence of the methyl and methoxy groups can also affect the binding affinity of RNA to proteins and other nucleic acids, making it a subject of interest in molecular biology and biochemistry research.

Formula: C₁₁H₁₆N₂O₆

InChI: InChI=1S/C11H16N2O6/c1-5-3-13(11(17)12-9(5)16)10-8(18-2)7(15)6(4-14)19-10/h3,6-8,10,14-15H,4H2,1-2H3,(H,12,16,17)/t6-,7-,8-,10-/m1/s1

InChI key: InChIKey=YHRRPHCORALGKQ-FDDDBJFASA-N

SMILES: O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C(C)=C2

Synonyms:

• 1-[(2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
• 2'-O-Methyl-5-methyl-D-uridine
• 2′-O-Methylribothymidine
• 5,2'-O-Dimethyluridine
• 5-Methyl-2'-O-methyluridine
• uridine, 5-methyl-2'-O-methyl-
• 2′-O-Methylthymidine
• 2′-O-Methyl-5-methyluridine

5-Methyl-2'-O-methyluridine

CAS: 55486-09-4

Formula: C₁₁H₁₆N₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 272.2545

Ref: IN-DA0039V9

5-Me-2'-Ome Uridine

CAS: 55486-09-4

5-Me-2'-Ome Uridine

Purity: 97%

Molecular weight: 272.25g/mol

Ref: 54-OR1028373

2'-O-Methyl-5-methyl uridine

CAS: 55486-09-4

2'-O-Methyl-5-methyl uridine is a 2'-O-Methyl nucleoside.

Formula: C₁₁H₁₆N₂O₆

Color and Shape: Solid

Molecular weight: 272.25

Ref: TM-TNU0716

5-Methyl-2’-O-methyluridine

Controlled Product

CAS: 55486-09-4

Applications 5-Methyl-2’-O-methyluridine is one of three oligonucleotide in platinum-derivatized homopyrimidine triplex-forming oligonucleotides (Pt-TFOs) useful in crosslinking to the transcribed strand in the human androgen receptor (AR) gene. Inhibitory activity against M. bovis and M. avium.
References Graham, M. K., et al.: Biochem., 54, 2270-2282 (2015); Johar, M., et al.: Bioorg. Med. Chem., 13, 6663-6671 (2005)

Formula: C₁₁H₁₆N₂O₆

Color and Shape: Neat

Molecular weight: 272.25

Ref: TR-M263415

2'-O-Methyl-5-methyluridine

CAS: 55486-09-4

2'-O-Methyl-5-methyluridine is a nucleoside that is involved in the synthesis of RNA. It is a component of the 5-methyluridine (5MU) and 2'-O-methyl-5-hydroxymethyluridine (2'OMMU) families of nucleotides. This compound has been shown to be effective against organisms such as E. coli, S. typhimurium, and C. parapsilosis, which are amide sensitive. The amide group of 2'-O-methyl-5-methyluridine can be cleaved by reagents such as hydrazine or tris(2,4,6,-trimethlyphenyl)phosphonium bromide to form 5MU and 2'OMMU respectively. The modifications to the ribose ring are important for its activity and function in cells. The modification of the ribose ring is catalyzed by enzymes called

Formula: C₁₁H₁₆N₂O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 272.25 g/mol

Ref: 3D-NM01238

5-METHYL-2-O-METHYLURIDINE

CAS: 55486-09-4

Formula: C₁₁H₁₆N₂O₆

Purity: 97%

Color and Shape: Solid

Molecular weight: 272.257

Ref: 10-F463461