Substance P, particularly the variant known as (Tyr^8)-substance P, is a neuropeptide that plays a crucial role in the transmission of pain and the regulation of various physiological functions. It is an 11-amino acid peptide, with the sequence typically represented as Arg-Pro-Lys-Pro-Gln-Gly-Leu-Met-NH2, where the tyrosine at position 8 is modified. This modification enhances its biological activity and receptor binding affinity. (Tyr^8)-substance P interacts primarily with the neurokinin-1 (NK1) receptor, which is involved in pain perception, inflammation, and stress responses. The substance is known for its role in the central nervous system and peripheral tissues, influencing mood, anxiety, and neurogenic inflammation. Its CAS number, 55614-10-3, identifies it uniquely in chemical databases, facilitating research and application in pharmacology and neuroscience. Overall, (Tyr^8)-substance P is significant in both basic research and potential therapeutic contexts, particularly in pain management and neuropsychiatric disorders.

(tyr8)-substance P

55614-10-3: Substance P, particularly the variant known as (Tyr^8)-substance P, is a neuropeptide that plays a crucial role in the transmission of pain and the regulation of various physiological functions. It is an 11-amino acid peptide, with the sequence typically represented as Arg-Pro-Lys-Pro-Gln-Gly-Leu-Met-NH2, where the tyrosine at position 8 is modified. This modification enhances its biological activity and receptor binding affinity. (Tyr^8)-substance P interacts primarily with the neurokinin-1 (NK1) receptor, which is involved in pain perception, inflammation, and stress responses. The substance is known for its role in the central nervous system and peripheral tissues, influencing mood, anxiety, and neurogenic inflammation. Its CAS number, 55614-10-3, identifies it uniquely in chemical databases, facilitating research and application in pharmacology and neuroscience. Overall, (Tyr^8)-substance P is significant in both basic research and potential therapeutic contexts, particularly in pain management and neuropsychiatric disorders.

<p>Substance P is a neuropeptide that is synthesized from the precursor protein pro-opiomelanocortin (POMC). Substance P has been shown to be a potent inhibitor of the synthesis of proteins that are necessary for cell division. It also stimulates the release of inflammatory mediators and has been shown to have an activator effect on receptors. This product is used as a research tool in cell biology, biochemistry, and pharmacology.</p>

CAS 55614-10-3

(tyr8)-substance P

[Tyr8]-Substance P (0.5 mg vial)

Ref: 3D-PSP-4059-V