CAS 55658-47-4

Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?)

Description:

Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride is a chemical compound that belongs to the class of bleomycin derivatives, which are known for their use in cancer treatment due to their ability to induce DNA strand breaks. This compound features a complex structure that includes an amine group, which contributes to its biological activity. As a hydrochloride salt, it is typically more soluble in water, enhancing its bioavailability for therapeutic applications. The presence of the 4-aminobutyl group suggests potential interactions with cellular components, which may influence its pharmacological properties. Bleomycin derivatives are characterized by their ability to bind to DNA and generate free radicals, leading to cytotoxic effects on rapidly dividing cells, making them effective in chemotherapy regimens. However, the use of such compounds can be associated with side effects, including pulmonary toxicity. Overall, Bleomycinamide's unique structure and properties make it a subject of interest in medicinal chemistry and oncology research.

Formula: C₅₇H₈₉N₁₉O₂₁S₂·ClH

InChI: InChI=1/C57H89N19O21S2.ClH/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53(91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(89)67-13-8-34-71-30(20-98-34)54-72-29(19-99-54)50(88)66-12-7-11-64-10-6-5-9-58;/h16,19-21,23-27,31-32,36-45,55-56,64,68,77-79,81-85H,5-15,17-18,58-59H2,1-4H3,(H2,60,80)(H2,62,86)(H2,63,92)(H,65,69)(H,66,88)(H,67,89)(H,70,91)(H,74,87)(H,75,90)(H2,61,73,76);1H/t23-,24-,25-,26+,27+,31+,32-,36+,37+,38+,39-,40-,41+,42+,43+,44+,45+,55-,56+;/m1./s1

InChI key: InChIKey=NRVKJXFKQWUKCB-GIIHLZIVSA-N

SMILES: [C@H]([C@H](NC(=O)C1=NC([C@@H](NC[C@@H](C(N)=O)N)CC(N)=O)=NC(N)=C1C)C(N[C@@H]([C@H]([C@@H](C(N[C@H](C(NCCC2=NC(=CS2)C3=NC(C(NCCCNCCCCN)=O)=CS3)=O)[C@@H](C)O)=O)C)O)C)=O)(O[C@H]4[C@@H](O[C@H]5[C@@H](O)[C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O5)[C@@H](O)[C@H](O)[C@H](CO)O4)C6=CN=CN6.Cl

Synonyms:

• Bleomycin A₅ hydrochloride
• Bleomycinamide, N¹-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride
• Bleomycinamide, N¹-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?)
• N1-[3-[(4-Aminobutyl)amino]propyl]bleomycinamide hydrochloride
• Bleomycin A5 hydrochloride
• Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?)
• Bleomycinamide, N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride
• Bleomycin A5 HCl Salt
• Bleomycin A5 Hydrochlorid
• N -[3-(4-Aminobutyl)amino]propyl" hydrochloride
• BLEOCIN(TM), STREPTOMYCES VERTICILLUS, ＞85%
• n(sup1)-(3-((4-aminobutyl)amino)propyl)bleomycinamidehydrochloride
• n(sup1)-(3-((4-aminobutyl)amino)propyl)-bleomycinamidhydrochloride
• Bleomycin A5 Hydrochloride Salt
• BLEOMYCIN A5 HYDROCHLORIDE USP/EP/BP
• BLEOCIN(TM) ANTIBIOTIC
• BLEOCIN(TM)
• BleoMycin A5 Hydrochloride(PingyangMycin hydrochloride)

Bleomycin A5 Hydrochloride(1:x)

CAS: 55658-47-4

Formula: C₅₇H₉₀ClN₁₉O₂₁S₂

Purity: 85%

Color and Shape: Solid

Molecular weight: 1477.0222

Ref: IN-DA00DBZV

Bleomycin A5 HCl Salt

CAS: 55658-47-4

Formula: C₅₇H₈₉N₁₉O₂₁S₂·HCL

Molecular weight: 1440.57 36.46

Ref: 4Z-B-190002

Bleomycin A5 Hydrochloride Salt

CAS: 55658-47-4

Stability Hygroscopic
Applications Bleomycin A5 Hydrochloride Salt is used as an anti-cancer drug used to combat various forms of carcinoma via activated-apoptosis of cancer cells.
References Zochowska, M. et al.: PLoS One, 4 (2009); Zhao, J. et al.: Med. Onc., 28, 354 (2011);

Formula: C₅₇H₈₉N₁₉O₂₁S₂·ClH

Color and Shape: White To Light Yellow

Molecular weight: 1477.02

Ref: TR-B595750

Bleomycin A5 hydrochloride, copper complex

CAS: 55658-47-4

Bleomycin A5 inhibits DNA replication and repair. It also cleaves RNA in vitro and in vivo, and exhibits anticancer activity. It is used for various types of cancer such as squamous cell cancers, melanoma, sarcoma, testicular and ovarian cancer, Hodgkin's and non-Hodgkin's lymphoma.

Formula: C₅₇H₈₉CuN₁₉O₂₁S₂•(HCl)₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 1,613.49 g/mol

Ref: 3D-AB46332

Bleomycin A5

CAS: 55658-47-4

Formula: C₅₇H₈₉N₁₉O₂₁S₂HCl

Molecular weight: 1440.6 : 36.46

Ref: ST-EA-CP-B126005