CAS 55661-38-6

Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1)

Description:

Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1), commonly referred to by its CAS number 55661-38-6, is a chemical compound that features a complex structure incorporating a urea moiety, a pyrimidine derivative, and a nitroso group. This compound is characterized by its potential use in medicinal chemistry, particularly in the development of pharmaceuticals due to its unique functional groups that may exhibit biological activity. The presence of the chloroethyl group suggests possible reactivity, which could be leveraged in various chemical reactions or therapeutic applications. As a hydrochloride salt, it is typically more soluble in water, enhancing its bioavailability. The compound's stability, solubility, and reactivity can be influenced by environmental factors such as pH and temperature. Safety data should be consulted, as compounds with nitroso groups can be associated with toxicity and carcinogenicity. Overall, this compound represents a significant interest in both synthetic and medicinal chemistry fields.

Formula: C₉H₁₄Cl₂N₆O₂

InChI: InChI=1/C9H13ClN6O2.ClH/c1-6-12-4-7(8(11)14-6)5-13-9(17)16(15-18)3-2-10;/h4H,2-3,5H2,1H3,(H,13,17)(H2,11,12,14);1H

InChI key: InChIKey=KPMKNHGAPDCYLP-UHFFFAOYSA-N

SMILES: C(NC(N(CCCl)N=O)=O)C=1C(N)=NC(C)=NC1.Cl

Synonyms:

• 1-(4-Amino-2-methylpyrimidin-5-yl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride
• 3-[(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl]-1-(2-Chloroethyl)-1-Nitrosourea Hydrochloride
• 3-[(4-Amino-2-Methyl-Pyrimidin-5-Yl)Methyl]-1-(2-Chloroethyl)-1-Nitroso-Urea Hydrochloride
• Cs-439
• Nidran
• Nsc-D 245382
• Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, hydrochloride (1:1)
• Urea, N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-, monohydrochloride
• Nimustine hydrochloride
• ACNU
• 1-(2-cloroetil)-1-nitroso-3-((2-metil-4-aminopirimidin-5-il)metil)ureaclorhi
• n’-((4-amino-2-metil-5-pirimidinil)metil)-n-(2-cloroetil)-n-nitrosoureaclorh
• 1-(4-AMINO-2-METHYL-5-PYRIMIDINYL)-METHYL-3-(2-CHLOROETHYL)-3-NITROSOUREA HYDROCHLORIDE
• 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoureahydr
• NIMUSTINE HCL
• 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-1-(2-chloroethyl)-1-nitrosoureah
• 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-1-(2-chloroethyl)-1-nitroso-ure
• nsc-245,382
• n’-((4-amino-2-methyl-5-pyrimidinyl)methyl)-n-(2-chloroethyl)-n-nitrosourea
• nimustinaclorhidrato

Nimustine HCl

CAS: 55661-38-6

Formula: C₉H₁₄Cl₂N₆O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 309.1525

Ref: IN-DA003T3V

Nimustine Hydrochloride

CAS: 55661-38-6

Nimustine Hydrochloride

Purity: ≥98%

Molecular weight: 309.15g/mol

Ref: 54-BUP06279

Nimustine hydrochloride

CAS: 55661-38-6

Formula: C₉H₁₃ClN₆O₂

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 272.69

Ref: 7W-GP5132

Nimustine Hydrochloride

CAS: 55661-38-6

Nimustine Hydrochloride

Purity: 99%

Molecular weight: 309.15g/mol

Ref: 54-OR1027348

Nimustine Hydrochloride

CAS: 55661-38-6

Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.

Formula: C₉H₁₄Cl₂N₆O₂

Purity: 98.80%

Color and Shape: Solid

Molecular weight: 309.15

Ref: TM-T5017

Nimustine HCl

CAS: 55661-38-6

DNA crosslinking agent

Formula: C₉H₁₃ClN₆O₂·HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 309.15 g/mol

Ref: 3D-FN65105

Nimustine HCl - Bio-X ™

CAS: 55661-38-6

Nimustine is an antineoplastic agent that is being studied for use in treating Glioblastomas. It is suggested to be a DNA alkylating agent although, its exact mechanism is still unknown.

Formula: C₉H₁₃ClN₆O₂•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 309.15 g/mol

Ref: 3D-BN164659

Nimustine hydrochloride

CAS: 55661-38-6

Purity: 97%

Molecular weight: 309.1499939

Ref: 10-F862854

Nimustine Hydrochloride

Controlled Product

CAS: 55661-38-6

Applications Nimustine Hydrochloride is a DNA alkylator and cross-linking agent. It is used in chemotherapy in a part of anti-cancer cocktail used to treat malignant melanoma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Matsumoto, T. et al.: J. Eur. Acad. Dermatol. Venereol., 27, 1514 (2013);

Formula: C₉H₁₃ClN₆O₂·(HCl)

Color and Shape: Neat

Molecular weight: 272.69 + (36.46)

Ref: TR-N478253