CAS 5568-90-1

10H-Phenothiazine-10-ethanamine, N,N,β-trimethyl-, hydrochloride (1:1)

Description:

10H-Phenothiazine-10-ethanamine, N,N,β-trimethyl-, hydrochloride (1:1), commonly referred to as trimethobenzamide, is a chemical compound characterized by its phenothiazine structure, which consists of a tricyclic system containing sulfur and nitrogen atoms. This compound is typically encountered as a hydrochloride salt, enhancing its solubility in water and making it suitable for pharmaceutical applications. It exhibits properties as an antiemetic, primarily used to prevent nausea and vomiting associated with various conditions, including postoperative states and chemotherapy. The trimethylamine group contributes to its pharmacological activity, influencing its interaction with neurotransmitter receptors in the central nervous system. In terms of physical properties, it is usually a white to off-white crystalline powder, with a specific melting point range and solubility profile. Safety data indicates that, like many pharmaceuticals, it should be handled with care, as it may cause side effects or interactions with other medications. Overall, its unique structure and properties make it a significant compound in medicinal chemistry.

Formula: C₁₇H₂₁ClN₂S

InChI: InChI=1/C17H20N2S.ClH/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H

InChI key: InChIKey=RISCHQYUHLQSBU-UHFFFAOYSA-N

SMILES: C(CN(C)C)(C)N1C=2C(SC=3C1=CC=CC3)=CC=CC2.Cl

Synonyms:

• 10H-Phenothiazine-10-ethanamine, N,N,beta-trimethyl-, monohydrochloride (9CI)
• 10H-Phenothiazine-10-ethanamine, N,N,β-trimethyl-, hydrochloride (1:1)
• 10H-Phenothiazine-10-ethanamine, N,N,β-trimethyl-, monohydrochloride
• Isopromethazine hydrochloride
• Phenothiazine, 10-[2-(dimethylamino)-1-methylethyl]-, monohydrochloride
• Promethazine Impurity B (Isopromethazine) HCl
• Promethazine Impurity 2(EP Impurity B)
• N,N-dimethyl-2-phenothiazin-10-ylpropan-1-amine:hydrochloride
• Promethazine Impurity B
• PROMETHAZINE EP IMPURITY B HCL (ISOPROMETHAZINE HCL)
• ProMethazine EP IMpurity B
• N,N-dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine
• Promethazine EP Impurity B/ Promethazine Related Compound B (Isopromethazine)
• Promethazine Impurity 2(Promethazine EP Impurity B)

Isopromethazine hydrochloride

CAS: 5568-90-1

Isopromethazine hydrochloride

Color and Shape: White To Off-White

Ref: 47-778

Promethazine Related Compound B (N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride)

CAS: 5568-90-1

Compounds (excluding drugs) containing a phenothiazine ring-system (whether or not hydrogenated), not further fused

Formula: C₁₇H₂₀N₂S·HCl

Color and Shape: White Powder

Molecular weight: 320.1114

Ref: 45-1570029

Promethazine EP Impurity B HCl (Promethazine USP Related Compound B, Isopromethazine HCl)

CAS: 5568-90-1

Formula: C₁₇H₂₀N₂S·HCl

Color and Shape: Gray Solid

Molecular weight: 284.42 36.46

Ref: 4Z-P-186

Promethazine EP Impurity B (as Hydrochloride)

Controlled Product

CAS: 5568-90-1

Formula: C₁₇H₂₀N₂S·ClH

Color and Shape: Neat

Molecular weight: 320.88

Ref: 86-MM0412.02

Iso Promethazine Hydrochloride

CAS: 5568-90-1

Impurity Promethazine EP Impurity B
Stability Hygroscopic
Applications Iso Promethazine Hydrochloride (Promethazine EP Impurity B) is a Promethazine (P757000) impurity.
References Gasco, M.R., et al.: J. Pharma. Sci., 68, 612 (1979),

Formula: C₁₇H₂₀N₂S·ClH

Color and Shape: White To Off-White

Molecular weight: 320.88

Ref: TR-I822500

Promethazine related compound B

CAS: 5568-90-1

Promethazine is a phenothiazine derivative that is used as an antihistamine and antipsychotic. It has been found to bind to the H1 receptor, which may be the mechanism by which it inhibits histamine release. Promethazine also binds to the H2 receptor, which may be the mechanism by which it inhibits acid secretion in the stomach. Promethazine has been shown to have antiviral properties against herpes simplex virus type 1 (HSV-1) and human immunodeficiency virus (HIV). Promethazine can bind to metal ions and form a neutral complex that can inhibit receptors on cells. The drug has been shown to inhibit receptors for acetylcholine, dopamine, GABA, serotonin, histamine, and norepinephrine.

Formula: C₁₇H₂₀N₂S•HCl

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 320.88 g/mol

Ref: 3D-FAA56890

Promethazine EP Impurity B

CAS: 5568-90-1

Formula: C₁₇H₂₀N₂SHCl

Molecular weight: 284.42 : 36.46

Ref: ST-EA-CP-P86002