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CAS 5568-90-1

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10H-Phenothiazine-10-ethanamine, N,N,β-trimethyl-, hydrochloride (1:1)

Description:
10H-Phenothiazine-10-ethanamine, N,N,β-trimethyl-, hydrochloride (1:1), commonly referred to as trimethobenzamide, is a chemical compound characterized by its phenothiazine structure, which consists of a tricyclic system containing sulfur and nitrogen atoms. This compound is typically encountered as a hydrochloride salt, enhancing its solubility in water and making it suitable for pharmaceutical applications. It exhibits properties as an antiemetic, primarily used to prevent nausea and vomiting associated with various conditions, including postoperative states and chemotherapy. The trimethylamine group contributes to its pharmacological activity, influencing its interaction with neurotransmitter receptors in the central nervous system. In terms of physical properties, it is usually a white to off-white crystalline powder, with a specific melting point range and solubility profile. Safety data indicates that, like many pharmaceuticals, it should be handled with care, as it may cause side effects or interactions with other medications. Overall, its unique structure and properties make it a significant compound in medicinal chemistry.
Formula:C17H21ClN2S
InChI:InChI=1/C17H20N2S.ClH/c1-13(12-18(2)3)19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H
InChI key:InChIKey=RISCHQYUHLQSBU-UHFFFAOYSA-N
SMILES:C(CN(C)C)(C)N1C=2C(SC=3C1=CC=CC3)=CC=CC2.Cl
Synonyms:
  • 10H-Phenothiazine-10-ethanamine, N,N,beta-trimethyl-, monohydrochloride (9CI)
  • 10H-Phenothiazine-10-ethanamine, N,N,β-trimethyl-, hydrochloride (1:1)
  • 10H-Phenothiazine-10-ethanamine, N,N,β-trimethyl-, monohydrochloride
  • Isopromethazine hydrochloride
  • Phenothiazine, 10-[2-(dimethylamino)-1-methylethyl]-, monohydrochloride
  • Promethazine Impurity B (Isopromethazine) HCl
  • Promethazine Impurity 2(EP Impurity B)
  • N,N-dimethyl-2-phenothiazin-10-ylpropan-1-amine:hydrochloride
  • Promethazine Impurity B
  • PROMETHAZINE EP IMPURITY B HCL (ISOPROMETHAZINE HCL)
  • See more synonyms
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