CAS 55750-61-3

maleimidoacetic acid N-*hydroxysuccinimide ester

Description:

Maleimidoacetic acid N-hydroxysuccinimide ester, with the CAS number 55750-61-3, is a chemical compound commonly used in bioconjugation and protein labeling applications. This compound features a maleimide functional group, which is known for its ability to selectively react with thiol groups in proteins, facilitating the formation of stable thioether bonds. The presence of the N-hydroxysuccinimide (NHS) ester enhances the reactivity of the maleimide, allowing for efficient coupling to amine-containing molecules, such as amino acids or proteins. The compound is typically a white to off-white solid and is soluble in organic solvents like dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). Its reactivity and specificity make it valuable in various applications, including drug delivery systems, the development of biosensors, and the creation of antibody-drug conjugates. Proper handling and storage conditions are essential to maintain its stability and reactivity, as exposure to moisture or prolonged storage can lead to hydrolysis of the NHS ester.

Formula: C₁₀H₈N₂O₆

InChI: InChI=1/C10H8N2O6/c13-6-1-2-7(14)11(6)5-10(17)18-12-8(15)3-4-9(12)16/h1-2H,3-5H2

SMILES: C1=CC(=O)N(CC(=O)ON2C(=O)CCC2=O)C1=O

Synonyms:

• 1-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-oxoethyl}-1H-pyrrole-2,5-dione

N-Succinimidyl maleimidoacetate

CAS: 55750-61-3

Formula: C₁₀H₈N₂O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 252.1803

Ref: IN-DA003TC7

AMAS

CAS: 55750-61-3

AMAS

Purity: ≥98%

Molecular weight: 252.18g/mol

Ref: 54-BUP14695

2,5-Dioxopyrrolidin-1-Yl 2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Acetate

CAS: 55750-61-3

2,5-Dioxopyrrolidin-1-Yl 2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Acetate

Purity: 99%

Molecular weight: 252.18g/mol

Ref: 54-OR1010110

AMAS

CAS: 55750-61-3

AMAS is a non-claevable heterobifunctional crosslinker with NHS ester and maleimide groups that enables covalent conjugation of amine- and sulfhydryl-containing

Formula: C₁₀H₈N₂O₆

Purity: 99.98%

Color and Shape: Solid

Molecular weight: 252.18

Ref: TM-T17389

Maleimidoacetic Acid N-Hydroxysuccinimide Ester

Controlled Product

CAS: 55750-61-3

Applications A hetero-bifunctional cross-linking reagent for the preparation of protein-protein or protein-hapten conjugates.
References Kitagawa, T., et al.: Chem. Pharm. Bull., 29, 1130 (1981), Sayre., L.M., et al.: J. Med. Chem., 27, 1325 (1984)

Formula: C₁₀H₈N₂O₆

Color and Shape: Neat

Molecular weight: 252.18

Ref: TR-M125000

2,5-Dioxopyrrolidin-1-yl 2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)acetate

CAS: 55750-61-3

Formula: C₁₀H₈N₂O₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 252.182

Ref: 10-F448678

N-Succinimidyl Maleimidoacetate

CAS: 55750-61-3

Formula: C₁₀H₈N₂O₆

Purity: >95.0%(qNMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 252.18

Ref: 3B-S0968