CAS 55774-33-9

Azathioprine sodium

Description:

Azathioprine sodium is an immunosuppressive medication primarily used in the treatment of autoimmune diseases and to prevent organ transplant rejection. It is a prodrug that is metabolized into 6-mercaptopurine, which interferes with nucleic acid synthesis, thereby inhibiting the proliferation of lymphocytes. The compound is characterized by its chemical formula, which includes a thiopurine ring structure, contributing to its pharmacological activity. Azathioprine sodium is typically administered orally and is known for its potential side effects, including bone marrow suppression, gastrointestinal disturbances, and increased susceptibility to infections. It is important to monitor patients for these adverse effects during treatment. The drug's mechanism of action involves the inhibition of purine synthesis, which is crucial for DNA and RNA production in rapidly dividing cells, particularly lymphocytes. Due to its immunosuppressive properties, azathioprine sodium is often used in combination with other medications to enhance therapeutic efficacy while minimizing the risk of rejection in transplant patients.

Formula: C₉H₇N₇O₂S·Na

InChI: InChI=1S/C9H7N7O2S.Na/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8;/h2-4H,1H3,(H,10,11,12,13);

InChI key: InChIKey=OEMACMAHBHOELV-UHFFFAOYSA-N

SMILES: S(C1=C2C(N=CN2)=NC=N1)C3=C(N(=O)=O)N=CN3C.[Na]

Synonyms:

• 1H-Purine, 6-((1-methyl-4-nitro-1H-imidazol-5-yl)thio)-, sodium salt
• 7H-purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-, sodium salt (1:1)
• 9H-Purine, 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-, sodium salt (1:1)
• Azathioprine Sodium [USP]
• Azathioprine sodium salt
• Imuran
• Imuran injection
• Imurek
• Unii-Am94R510Ms
• Azathioprine sodium

Azathioprine Sodium

CAS: 55774-33-9

Azathioprine Sodium is a pro-drug converted to 6-MP, inhibiting DNA/RNA synthesis, curbing cell proliferation, especially in lymphocytes.

Formula: C₉H₆N₇NaO₂S

Color and Shape: Solid

Molecular weight: 299.24

Ref: TM-T69099