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CAS 5580-20-1

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4-thio-2'-deoxyuridine

Description:
4-Thio-2'-deoxyuridine is a nucleoside analog of thymidine, characterized by the substitution of a sulfur atom at the 4-position of the pyrimidine ring. This modification alters its biochemical properties and interactions within nucleic acid structures. The compound is typically used in biochemical research and has potential applications in antiviral and anticancer therapies due to its ability to interfere with nucleic acid synthesis. It exhibits a similar structure to natural nucleosides, allowing it to be incorporated into DNA during replication, which can lead to disruptions in normal cellular processes. The presence of the thiol group can also impart unique reactivity and stability characteristics compared to its non-thiated counterparts. Additionally, 4-thio-2'-deoxyuridine can be phosphorylated to form its triphosphate form, which is essential for its biological activity. Overall, this compound serves as a valuable tool in molecular biology and medicinal chemistry, providing insights into nucleic acid function and potential therapeutic pathways.
Formula:C9H12N2O4S
InChI:InChI=1/C9H12N2O4S/c12-4-6-5(13)3-8(15-6)11-2-1-7(16)10-9(11)14/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,16)/t5-,6+,8+/m0/s1
Synonyms:
  • 4-Thiodeoxyuridine
  • Nsc 517771
  • Uridine, 2'-deoxy-4-thio-
  • 7-methyl-2-thiophen-2-yl-5,6,7,8-tetrahydro-4H-[1]benzothieno[2,3-d][1,3]oxazin-4-one
  • 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-4-thioxo-3,4-dihydropyrimidin-2(1H)-one
  • 4-Thio-2'-deoxyuridine
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