CAS 55837-20-2: Halofuginone

Description: Halofuginone is a synthetic compound primarily recognized for its role as an anti-parasitic agent, particularly in veterinary medicine. It is derived from the natural product fugin, which is produced by certain fungi. The chemical structure of Halofuginone features a quinazolinone core, which contributes to its biological activity. This compound exhibits properties that inhibit collagen synthesis, making it useful in the treatment of various conditions related to fibrosis and inflammation. Halofuginone has been studied for its potential therapeutic applications beyond veterinary use, including its effects on autoimmune diseases and cancer. It is typically administered in the form of a salt, often as a hydrochloride. The compound is characterized by its moderate solubility in water and organic solvents, which influences its bioavailability and pharmacokinetics. Safety and efficacy profiles are essential considerations in its application, and ongoing research continues to explore its mechanisms of action and potential new uses in both veterinary and human medicine.

Formula: C₁₆H₁₇BrClN₃O₃

InChI: InChI=1/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2/t14-,15+/s2

InChI key: InChIKey=LVASCWIMLIKXLA-PVRQQBJHNA-N

SMILES: O=C1C=2C=C(Cl)C(Br)=CC2N=CN1CC(=O)CC3NCCCC3O

Synonyms:

• 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-, trans-
• 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, rel-
• 7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidyl]-2-oxopropyl]-4(3H)-quinazolinone
• 7-bromo-6-chloro-3-[3-(3-hydroxypiperidin-2-yl)-2-oxopropyl]quinazolin-4(3H)-one
• 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one
• 7-bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one
• 7-bromo-6-chloro-3-{3-[(3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one
• Kriptazen
• Tempostatin
• rel-7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone
• Halofuginone

7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidyl]-2-oxopropyl]-4(3H)-quinazolinone

CAS: 55837-20-2

• Formula: C₁₆H₁₇BrClN₃O₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 414.6815

Rel-7-Bromo-6-Chloro-3-(3-((2R,3S)-3-Hydroxypiperidin-2-Yl)-2-Oxopropyl)Quinazolin-4(3H)-One

CAS: 55837-20-2

• Purity: 98%
• Molecular weight: 414.68g/mol

Halofuginone

CAS: 55837-20-2

• Purity: ≥95%
• Molecular weight: 414.68g/mol

Halofuginone

CAS: 55837-20-2

• Formula: C₁₆H₁₇BrClN₃O₃
• Purity: 95%~99%
• Molecular weight: 414.684

7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidyl]-2-oxopropyl]-4(3H)-quinazolinone

CAS: 55837-20-2

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• Formula: C₁₆H₁₇BrClN₃O₃
• Color and Shape: Powder
• Molecular weight: 414.68 g/mol

Halofuginone

CAS: 55837-20-2

Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.

• Formula: C₁₆H₁₇BrClN₃O₃
• Purity: 97.67%
• Color and Shape: Off-White Solid
• Molecular weight: 414.68

Halofuginone

CAS: 55837-20-2

• Formula: C₁₆H₁₇BrClN₃O₃
• Color and Shape: Neat
• Molecular weight: 414.682