CAS 55837-20-2

Halofuginone

Description:

Halofuginone is a synthetic compound primarily recognized for its role as an anti-parasitic agent, particularly in veterinary medicine. It is derived from the natural product fugin, which is produced by certain fungi. The chemical structure of Halofuginone features a quinazolinone core, which contributes to its biological activity. This compound exhibits properties that inhibit collagen synthesis, making it useful in the treatment of various conditions related to fibrosis and inflammation. Halofuginone has been studied for its potential therapeutic applications beyond veterinary use, including its effects on autoimmune diseases and cancer. It is typically administered in the form of a salt, often as a hydrochloride. The compound is characterized by its moderate solubility in water and organic solvents, which influences its bioavailability and pharmacokinetics. Safety and efficacy profiles are essential considerations in its application, and ongoing research continues to explore its mechanisms of action and potential new uses in both veterinary and human medicine.

Formula: C₁₆H₁₇BrClN₃O₃

InChI: InChI=1/C16H17BrClN3O3/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14/h5-6,8,14-15,19,23H,1-4,7H2/t14-,15+/s2

InChI key: InChIKey=LVASCWIMLIKXLA-PVRQQBJHNA-N

SMILES: O=C1C=2C(N=CN1CC(C[C@H]3[C@H](O)CCCN3)=O)=CC(Br)=C(Cl)C2

Synonyms:

• 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-, trans-
• 4(3H)-Quinazolinone, 7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-, rel-
• 7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidyl]-2-oxopropyl]-4(3H)-quinazolinone
• 7-bromo-6-chloro-3-[3-(3-hydroxypiperidin-2-yl)-2-oxopropyl]quinazolin-4(3H)-one
• 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one
• 7-bromo-6-chloro-3-{3-[(2S,3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one
• 7-bromo-6-chloro-3-{3-[(3R)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one
• Kriptazen
• Tempostatin
• rel-7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone
• Halofuginone

7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidyl]-2-oxopropyl]-4(3H)-quinazolinone

CAS: 55837-20-2

Formula: C₁₆H₁₇BrClN₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 414.6815

Ref: IN-DA0039CM

Rel-7-Bromo-6-Chloro-3-(3-((2R,3S)-3-Hydroxypiperidin-2-Yl)-2-Oxopropyl)Quinazolin-4(3H)-One

CAS: 55837-20-2

Rel-7-Bromo-6-Chloro-3-(3-((2R,3S)-3-Hydroxypiperidin-2-Yl)-2-Oxopropyl)Quinazolin-4(3H)-One

Purity: 98%

Molecular weight: 414.68g/mol

Ref: 54-OR1026218

Halofuginone

CAS: 55837-20-2

Halofuginone

Purity: ≥95%

Molecular weight: 414.68g/mol

Ref: 54-BUP12256

Halofuginone

CAS: 55837-20-2

Formula: C₁₆H₁₇BrClN₃O₃

Purity: 95%~99%

Molecular weight: 414.684

Ref: BP-BP4353-1

7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidyl]-2-oxopropyl]-4(3H)-quinazolinone

CAS: 55837-20-2

Please enquire for more information about 7-Bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidyl]-2-oxopropyl]-4(3H)-quinazolinone including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₆H₁₇BrClN₃O₃

Color and Shape: Powder

Molecular weight: 414.68 g/mol

Ref: 3D-FB29543

Halofuginone

Controlled Product

CAS: 55837-20-2

Formula: C₁₆H₁₇BrClN₃O₃

Color and Shape: Neat

Molecular weight: 414.682

Ref: TR-H102510

Halofuginone

CAS: 55837-20-2

Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.

Formula: C₁₆H₁₇BrClN₃O₃

Purity: 99.53%

Color and Shape: Off-White Solid

Molecular weight: 414.68

Ref: TM-T6856