CAS 55873-09-1

2-chloropyrimidin-4(3H)-one

Description:

2-Chloropyrimidin-4(3H)-one, with the CAS number 55873-09-1, is a heterocyclic organic compound characterized by a pyrimidine ring substituted with a chlorine atom and a keto group. This compound features a six-membered aromatic ring containing two nitrogen atoms at the 1 and 3 positions, which contributes to its basicity and reactivity. The presence of the chlorine atom at the 2-position enhances its electrophilic character, making it a useful intermediate in various chemical syntheses, particularly in the development of pharmaceuticals and agrochemicals. The keto group at the 4-position plays a crucial role in its reactivity, allowing for potential tautomerization and participation in nucleophilic addition reactions. 2-Chloropyrimidin-4(3H)-one is typically a solid at room temperature and is soluble in polar organic solvents. Its unique structure and functional groups make it a valuable compound in medicinal chemistry, where it can serve as a scaffold for the design of biologically active molecules.

Formula: C₄H₃ClN₂O

InChI: InChI=1/C4H3ClN2O/c5-4-6-2-1-3(8)7-4/h1-2H,(H,6,7,8)

Synonyms:

• 2-chloropyrimidin-4(1H)-one
• 2-Chlorpyrimidin-4(1H)-on
• 4-Pyrimidinol, 2-Chloro-
• 2-Chloro-4-hydroxypyrimidine

2-Chloro-4(3H)-pyrimidinone

CAS: 55873-09-1

Formula: C₄H₃ClN₂O

Purity: 95%

Color and Shape: Solid

Molecular weight: 130.5324

Ref: IN-DA0039R8

2-Chloro-4-hydroxypyrimidine

CAS: 55873-09-1

2-Chloro-4-hydroxypyrimidine

Purity: 95%

Molecular weight: 130.53g/mol

Ref: 54-OR925753

Pazopanib Impurity 24

CAS: 55873-09-1

Formula: C₄H₃ClN₂O

Color and Shape: White To Off-White Solid

Molecular weight: 130.53

Ref: 4Z-P-129009

2-chloro-3,4-dihydropyrimidin-4-one

CAS: 55873-09-1

Purity: 95%

Molecular weight: 130.5299988

Ref: 10-F791605

2-Chloro-4-hydroxypyrimidine

CAS: 55873-09-1

2-Chloro-4-hydroxypyrimidine is a reactive heterocycle that belongs to the group of quinazolines. It can be synthesized by reacting pyrimidine with thiophosgene and thiol in an analogous reaction, or through the substitution of amino acids with isothiocyanate. Analogues of this compound exist that have been shown to be chemoselective for the replacement of 2-chloro-4-hydroxypyrimidine residues in proteins.

Formula: C₄H₃ClN₂O

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 130.53 g/mol

Ref: 3D-FC137924

2-Chloropyrimidin-4-ol

CAS: 55873-09-1

Formula: C₄H₃ClN₂O

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 130.53

Ref: 10-F233671

2-Chloro-4(1H)-pyrimidinone Hydrochloride

Controlled Product

CAS: 55873-09-1

Applications 2-Chloro-4(1H)-pyrimidinone Hydrochloride is a reactant in the preparation of aminobenzamide derivatives as glycogen synthase kinase 3β (GSK3β) inhibitors for preventing or treating GSK3β-mediated diseases (1).
References (1) Freyne, E.J.E., et al.: PCT Int. Appl., WO 2003037877 (2003

Formula: C₄H₃ClN₂O•HCl

Color and Shape: Neat

Molecular weight: 166.99

Ref: TR-C367705

Pazopanib Impurity 2

CAS: 55873-09-1

Formula: C₄H₃ClN₂O

Molecular weight: 130.5

Ref: ST-EA-CP-P58019