CAS 55879-47-5

6-Hydroxydexamethasone

Description:

6-Hydroxydexamethasone is a synthetic glucocorticoid and a derivative of dexamethasone, which is commonly used for its anti-inflammatory and immunosuppressive properties. This compound features a hydroxyl group at the 6-position of the steroid backbone, which alters its pharmacological profile compared to its parent compound. It is typically characterized by its white to off-white crystalline appearance and is soluble in organic solvents such as ethanol and dimethyl sulfoxide, but has limited solubility in water. The molecular formula of 6-Hydroxydexamethasone reflects its steroid structure, which is essential for its biological activity. It interacts with glucocorticoid receptors, influencing gene expression and modulating various physiological processes, including inflammation and immune response. Due to its potent effects, it is important to use this compound under medical supervision, as it can have significant side effects and contraindications. Overall, 6-Hydroxydexamethasone serves as an important tool in therapeutic applications, particularly in treating conditions that require modulation of the immune system.

Formula: C₂₂H₂₉FO₆

InChI: InChI=1S/C22H29FO6/c1-11-6-13-14-8-16(26)15-7-12(25)4-5-19(15,2)21(14,23)17(27)9-20(13,3)22(11,29)18(28)10-24/h4-5,7,11,13-14,16-17,24,26-27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16-,17+,19+,20+,21+,22+/m1/s1

InChI key: InChIKey=RVBSTEHLLHXILB-QODHSQIYSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)[C@H](C)C3)[H])(C[C@@H](O)C=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (6β,11β,16α)-9-Fluoro-6,11,17,21-tetrahydroxy-16-methylpregna-1,4-diene-3,20-dione
• 6-Hydroxydexamethasone
• 6β-Hydroxydexamethasone
• Pregna-1,4-Diene-3,20-Dione, 9-Fluoro-6,11,17,21-Tetrahydroxy-16-Methyl-, (6Beta,11Beta,16Alpha)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-6,11,17,21-tetrahydroxy-16-methyl-, (6β,11β,16α)-

6-β-Hydroxy Dexamethasone

CAS: 55879-47-5

Formula: C₂₂H₂₉FO₆

Color and Shape: White To Off-White Solid

Molecular weight: 408.47

Ref: 4Z-D-3640

6β-hydroxy Dexamethasone

CAS: 55879-47-5

6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound.

Formula: C₂₂H₂₉FO₆

Color and Shape: Solid

Molecular weight: 408.46

Ref: TM-T37361

6β-Hydroxy Dexamethasone

CAS: 55879-47-5

Applications The hydrophilic metabolite of Dexamethasone (D298800).
References Draper, R., et al.: Drug Res., 32, 317 (1982), Watkins, P., et al.: Clin. Pharmacol. Ther., 52, 265 (1992), Yamamoto, N., et al.: J. Clin. Oncol., 18, 2301 (2000), Slaviero, K., et al.: Br. J. Clin. Pharmacol., 57, 44 (2004),

Formula: C₂₂H₂₉FO₆

Color and Shape: White

Molecular weight: 408.46

Ref: TR-H939500

6-Hydroxy dexamethasone

Controlled Product

CAS: 55879-47-5

6-Hydroxy dexamethasone is a synthetic glucocorticoid. It is not known whether this drug undergoes microbial biotransformation. In humans, the main metabolite of 6-hydroxy dexamethasone is 6-keto-dexamethasone, which has been found in urine and saliva as well as in human liver tissue. The metabolism of 6-hydroxy dexamethasone has been studied by 13C NMR spectroscopy and magnetic resonance spectroscopy. This drug undergoes side chain cleavage to form various metabolites with different metabolic profiles. These metabolites have been detected in urine, faeces, and blood plasma after oral administration of the drug to humans.

Formula: C₂₂H₂₉FO₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 408.46 g/mol

Ref: 3D-FH44906

6β-Hydroxy Dexamethasone

CAS: 55879-47-5

Formula: C₂₂H₂₉FO₆

Molecular weight: 408.47

Ref: ST-EA-CP-D17057