CAS 5591-45-7

Thiothixene

Description:

Thiothixene is an antipsychotic medication primarily used in the treatment of schizophrenia and other psychotic disorders. It belongs to the thioxanthene class of drugs and functions as a dopamine receptor antagonist, particularly targeting D2 receptors in the brain. This action helps to alleviate symptoms such as hallucinations and delusions. Thiothixene is characterized by its chemical structure, which includes a thioxanthene core, contributing to its pharmacological properties. The substance is typically administered in oral form and is known for its potential side effects, which may include sedation, weight gain, and extrapyramidal symptoms. It is important to monitor patients for these effects during treatment. Additionally, thiothixene has a relatively long half-life, allowing for once or twice daily dosing. As with all antipsychotic medications, careful consideration of the risk-benefit profile is essential, and it should be prescribed under the guidance of a qualified healthcare professional.

Formula: C₂₃H₂₉N₃O₂S₂

InChI: InChI=1/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8+

InChI key: InChIKey=GFBKORZTTCHDGY-UHFFFAOYSA-N

SMILES: C(CCN1CCN(C)CC1)=C2C=3C(SC=4C2=CC=CC4)=CC=C(S(N(C)C)(=O)=O)C3

Synonyms:

• 2-(Dimethylsulfamoyl)-[9-(4-methyl-1-piperazinyl)propylidene]thioxanthene
• Cp 12252-1
• N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide
• N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]thioxanthene-2-sulfonamide
• N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propyliden]-9H-thioxanthen-2-sulfonamid
• N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulphonamide
• N,N-dimethyl-9-[3-(4-methylpiperazine-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
• N,N-dimetil-9-[3-(4-metilpiperazin-1-il)propiliden]-9H-tioxanteno-2-sulfonamida
• Navan
• Navane
• Navaron
• Nsc 108165
• Orbinamon
• P 4657B
• Thiothixene
• Thioxanthene-2-sulfonamide, N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-
• Thixit
• Tiotixene
• cis-Thiothixene
• 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-
• N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide
• (9E)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
• N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
• n,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thiaxanthene-2-sulfona
• N,N-Dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thiaxanthene-2-sulfonamide
• 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, (Z)-
• 9h-thioxanthene-2-sulfonamide,n,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propyl
• n,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thioxanthene-2-sulfona
• TIOTIXENE/THIOTHIXENE
• THIOTHIXENE,USP
• THIOTHIXENE MEETS USP TESTING SPECIFICA
• CP-12,252-1 base
• (Z)-N,N-dimethyl-9-(3-(4-methylpiperazin-1-yl)
• Thiothixine
• n,n-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)thioxanthene-2-sulfonami
• Thiothixene (Navane)
• (9Z)-N,N-Dimethyl-9-[3-(4-methyl-1-piperazinyl)propylidene]-9H-thioxanthene-2-sulfonamide
• cp12252-1

Thiothixene

CAS: 5591-45-7

Thiothixene has a wide range of applications in life science related research.

Formula: C₂₃H₂₉N₃O₂S₂

Color and Shape: Solid

Molecular weight: 443.62

Ref: TM-T38200

Thiothixene-13C-d3

CAS: 5591-45-7

Formula: C₂₂₁₃CH₂₆D₃N₃O₂S₂

Molecular weight: 447.63

Ref: 4Z-T-228002

(Z)-Thiothixene-d8

Controlled Product

CAS: 5591-45-7

Formula: C₂₃H₂₁D₈N₃O₂S₂

Color and Shape: Neat

Molecular weight: 451.67

Ref: TR-T375283

Thiothixene-d8

Controlled Product

CAS: 5591-45-7

Thiothixene is a drug used to treat schizophrenia that belongs to the class of antipsychotics. It is a serotonin reuptake inhibitor and has been shown to be effective in treating chronic schizophrenia. Thiothixene also has anti-nervous system activities, which are due to its ability to inhibit the release of acetylcholine. This drug binds with high affinity to α7 nicotinic acetylcholine receptors and blocks the flow of chloride ions across the cell membrane, leading to an accumulation of negatively charged ions inside the cell. The drug also inhibits mineralization and has been shown to prevent structural heart disease in animals. Thiothixene may be harmful if taken with pyrite or salinity because it can cause oxidative damage in redox potential environments. The drug can also cause plasma mass spectrometry profiles that show changes in carboniferous content, which may be related to the development of nervous system diseases.

Formula: C₂₃H₂₁D₈N₃O₂S₂

Purity: Min. 95%

Molecular weight: 451.67 g/mol

Ref: 3D-FAA59145