CAS 55916-51-3

Polyphyllin VI

Description:

Polyphyllin VI is a natural steroidal saponin primarily derived from the plant species of the genus Paris, particularly Paris polyphylla. It is characterized by its complex molecular structure, which includes a steroid backbone and multiple sugar moieties, contributing to its saponin properties. This compound is known for its potential pharmacological activities, including anti-inflammatory, anticancer, and immunomodulatory effects. Polyphyllin VI exhibits a range of biological activities, which have garnered interest in medicinal chemistry and pharmacology. Its mechanism of action often involves the induction of apoptosis in cancer cells and modulation of various signaling pathways. Additionally, due to its saponin nature, it can exhibit surfactant properties, influencing membrane permeability. However, the use of Polyphyllin VI in therapeutic applications requires careful consideration of its bioavailability and potential toxicity. As research continues, further elucidation of its pharmacokinetics and mechanisms of action may enhance its applicability in clinical settings.

Formula: C₃₉H₆₂O₁₃

InChI: InChI=1S/C39H62O13/c1-18-8-13-38(47-17-18)20(3)39(46)27(52-38)15-25-23-7-6-21-14-22(9-11-36(21,4)24(23)10-12-37(25,39)5)49-35-33(31(44)29(42)26(16-40)50-35)51-34-32(45)30(43)28(41)19(2)48-34/h6,18-20,22-35,40-46H,7-17H2,1-5H3/t18-,19+,20-,22+,23-,24+,25+,26-,27+,28+,29-,30-,31+,32-,33-,34+,35-,36+,37+,38-,39-/m1/s1

InChI key: InChIKey=WHWWQGPCTUQCMN-JDDKMXSSSA-N

SMILES: O[C@@]12[C@]3(C)[C@@](C[C@@]1(O[C@@]4([C@H]2C)CC[C@@H](C)CO4)[H])([C@]5([C@](CC3)([C@]6(C)C(=CC5)C[C@@H](O[C@H]7[C@H](O[C@H]8[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](O)[C@H](O)[C@@H](CO)O7)CC6)[H])[H])[H]

Synonyms:

• (3β,25R)-17-Hydroxyspirost-5-en-3-yl 2-O-(6-deoxy-α-<span class="text-smallcaps">L</smallcap>-mannopyranosyl)-β-<smallcap>D</span>-glucopyranoside
• 17-Hydroxyparis V
• Paris VI
• Paris saponin VI
• ParisVI
• Pennogenin 3-O-a-L-rhamnopyranosyl-(1® 2)-b-D-glucopyranoside
• Pennogenin 3-O-α-<span class="text-smallcaps">L</smallcap>-rhamnopyranosyl-(1→2)-β-<smallcap>D</span>-glucopyranoside
• Pennogenin-3-O-α-<span class="text-smallcaps">L</smallcap>-rhamnopyranosyl(1→2)-β-<smallcap>D</span>-glucoside
• Polygonatoside B3
• Polygonatoside B³
• Polyphyllin VI
• Saponin Tb
• β-<span class="text-smallcaps">D</smallcap>-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl 2-O-(6-deoxy-α-<smallcap>L</span>-mannopyranosyl)-
• Pennogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside
• β-D-Glucopyranoside, (3β,25R)-17-hydroxyspirost-5-en-3-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-

Polyphyllin VI

CAS: 55916-51-3

Formula: C₃₉H₆₂O₁₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 738.9018

Ref: IN-DA00DCD0

Polyphyllin VI

CAS: 55916-51-3

Polyphyllin VI

Purity: 98%

Molecular weight: 738.9g/mol

Ref: 54-OR1022944

Polyphyllin VI

CAS: 55916-51-3

Polyphyllin VI

Purity: ≥98%

Molecular weight: 738.9g/mol

Ref: 54-BUP00093

Polyphyllin VI

CAS: 55916-51-3

Formula: C₃₉H₆₂O₁₃

Molecular weight: 738.91

Ref: 7W-GY9377

Polyphyllin VI

CAS: 55916-51-3

Formula: C₃₉H₆₂O₁₃

Purity: 95%~99%

Molecular weight: 738.912

Ref: BP-BP1131

Polyphyllin VI

CAS: 55916-51-3

1. Polyphyllin VI has hemostasis , expectorant , bacteriostasis, anticytotoxic, anti pregnancy kill sperm effects.

Formula: C₃₉H₆₂O₁₃

Purity: 99.69% - 99.72%

Color and Shape: Solid

Molecular weight: 738.9

Ref: TM-T6S2315

Polyphyllin VI

CAS: 55916-51-3

Polyphyllin VI is a natural compound that belongs to the class of polyphyllins. It is a reactive compound with a p-gp substrate and mitochondrial membrane potential. Polyphyllin VI has been shown to be an effective inhibitor of bacterial growth and is clinically relevant in the treatment of bacterial infections. This drug also inhibits the synthesis of fatty acids, which may cause it to exhibit anti-inflammatory effects due to its ability to inhibit prostaglandin synthesis. Polyphyllin VI also shows antioxidant properties, which may be due to its ability to scavenge free radicals and protect cells from oxidative damage.

Formula: C₃₉H₆₂O₁₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 738.9 g/mol

Ref: 3D-FP59479

Polyhyllin VI

Controlled Product

CAS: 55916-51-3

Applications Polyhyllin VI is a natural saponin extracted from the plant, Rhizoma Paridis, and displays anti-proliferative activity in vivo. Used in the treatment of HepG2 cells for tumor mitigation.
References Ma, D. et al.: J. Int Med. Res., 37, 631 (2009); Yin, X. et al.: Biomed. Chrom., 27, 343 (2013); Jiang, H. et al.: Mol. Med. Rep., 9, 2265 (2014); Cheng, Z. et al.: J. Ethnopharmacol., 120, 129 (2008);

Formula: C₃₉H₆₂O₁₃

Color and Shape: Neat

Molecular weight: 738.9

Ref: TR-P689480