CAS 55968-37-1

3'-deoxyguanosine 5'-(tetrahydrogen triphosphate)

Description:

3'-Deoxyguanosine 5'-(tetrahydrogen triphosphate), commonly referred to as dGTP, is a nucleotide that plays a crucial role in cellular metabolism and biochemistry. It is a derivative of guanosine, lacking the hydroxyl group at the 3' position of the ribose sugar, which makes it a deoxynucleotide. The molecule consists of a guanine base attached to a deoxyribose sugar, which is further linked to a triphosphate group. This triphosphate moiety is essential for energy transfer and is involved in various biochemical processes, including DNA synthesis and repair. dGTP serves as a substrate for DNA polymerases during DNA replication, contributing to the elongation of the DNA strand. The compound is typically found in its hydrated form and is sensitive to hydrolysis, which can affect its stability and reactivity. Its CAS number, 55968-37-1, is a unique identifier that facilitates the cataloging and identification of this specific chemical substance in scientific literature and databases.

Formula: C₁₀H₁₆N₅O₁₃P₃

InChI: InChI=1/C10H16N5O13P3/c11-10-13-7-6(8(17)14-10)12-3-15(7)9-5(16)1-4(26-9)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-5,9,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,9+/m0/s1

3'-Deoxy-GTP

CAS: 55968-37-1

3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is an analog of GTP and serves as an RNA chain terminator, effectively inhibiting RNA synthesis. It can inhibit dengue virus DENV NS5 RdRp with an IC50 of 0.02 μM.

Formula: C₁₀H₁₆N₅O₁₃P₃

Color and Shape: Solid

Molecular weight: 507.181

Ref: TM-T206927