CAS 55981-09-4

Nitazoxanide

Description:

Nitazoxanide is an antiparasitic and antiviral compound primarily used in the treatment of various infections, including those caused by protozoa and certain viruses. It is classified as a thiazolide and exhibits a broad spectrum of activity against a range of pathogens. The chemical structure of nitazoxanide features a thiazole ring, which contributes to its pharmacological properties. It works by inhibiting the enzyme pyruvate:ferredoxin oxidoreductase, disrupting the energy metabolism of the target organisms. Nitazoxanide is typically administered orally and is known for its relatively low toxicity profile. It is often used in combination with other medications to enhance therapeutic efficacy. The compound is also being investigated for its potential use against various viral infections, including influenza and coronaviruses. Its solubility and stability in different pH environments make it suitable for formulation in various dosage forms. Overall, nitazoxanide represents a significant advancement in the treatment of infectious diseases, showcasing the importance of chemical compounds in modern medicine.

Formula: C₁₂H₉N₃O₅S

InChI: InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)

InChI key: InChIKey=YQNQNVDNTFHQSW-UHFFFAOYSA-N

SMILES: C(NC=1SC(N(=O)=O)=CN1)(=O)C2=C(OC(C)=O)C=CC=C2

Synonyms:

• 2-(Acetyloxy)-N-(5-nitro-2-thiazolyl)benzamide
• 2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
• Alinia
• Brn 1225475
• Cryptaz
• Daxon
• Dexidex
• Drg 0242
• Kidonax
• Mitafar
• N-(5-Nitro-2-thiazolyl)salicylamide acetate (ester)
• NTX
• NTZ
• Nitacure
• Nitacure 500
• Nitarid
• Nitazode
• Nitazox 500
• Nitazoxanida
• Nitazoxanide
• Nixide
• Nixoran
• Nizonide
• Nsc 697855
• Pacovanton
• ParaMix
• Ph 5776
• Xerovirin-C
• acetate de o-[N-(5-nitrothiazole-2-yl)carbamoyl]phenyle
• acetato de o-[N-(5-nitrotiazol-2-il)carbamoil]fenilo
• o-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenylacetat
• o-[N-(5-nitrothiazol-2-yl)carbamoyl]phenyl acetate

Nitazoxanide

CAS: 55981-09-4

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Formula: C₁₂H₉N₃O₅S

Color and Shape: Light Yellow Yellow Powder

Molecular weight: 307.02629

Ref: 45-1463960

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide (NSC-697855) is a synthetic benzamide antiprotozoal; it disrupts pyruvate electron transfer reactions.

Formula: C₁₂H₉N₃O₅S

Purity: 99% - 99.93%

Color and Shape: Solid

Molecular weight: 307.28

Ref: TM-T1546

Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 307.2820

Ref: IN-DA00I9ZK

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide

Purity: 99%

Molecular weight: 307.28g/mol

Ref: 54-OR1025226

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide

Purity: ≥95%

Molecular weight: 307.28g/mol

Ref: 54-BUP17783

Nitazoxanide

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 307.28

Ref: 3B-N1031

Nitazoxanide

Controlled Product

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Color and Shape: Light Yellow Crystalline

Molecular weight: 307.28

Ref: 86-MM3279.00

Nitrazoxanide

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Color and Shape: Neat

Molecular weight: 307.28

Ref: 04-C15552000

Nitazoxanide

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Molecular weight: 307.28

Ref: 7W-GP0229

Nitazoxanide

Controlled Product

CAS: 55981-09-4

Applications An anthelmintic (cestodes), antiprotozoal (cryptosporidium). Kills Mycobacterium tuberculosis.
References Cavier, R., et al.: Eur. J. Med. Chem.-Chim. Ther., 13, 539 (1978), Dubreuil, L., et al.: Antimicrob. Ag. Chemother., 40, 2266 (1996), Stockis, A., et al.: Int. J. Clin. Pharmacol. Ther., 34, 349 (1996), Nathan, C., et al.: J. Med. Chem. 52, 5789 (2009); de Carvalho et. al., J. Med. Chem., 52, 5789 (2009)

Formula: C₁₂H₉N₃O₅S

Color and Shape: Light Yellow Crystalline

Molecular weight: 307.28

Ref: TR-N490100

Nitazoxanide - Bio-X ™

CAS: 55981-09-4

Nitazoxanide acts as a noncompetitive inhibitor of the pyruvate: ferredoxin/flavodoxin oxidoreductases of various microorganism with Ki values between 2 and 10 μM. Nitazoxanide is clinically relevant for its broad-spectrum action to reduce the growth of bacteria, various parasites, and especially for its efficacy against the pathogen Helicobacter pylori. Nitazoxanide also has been shown to be effective in treating inflammatory bowel disease and acute enteritis caused by bacteria. In 2021, nitazoxanide was tested for the treatment of COVID-19 patients with mild symptoms due to its broad antiviral action.

Formula: C₁₂H₉N₃O₅S

Purity: Min. 90 Area-%

Color and Shape: Powder

Molecular weight: 307.28 g/mol

Ref: 3D-BN164151

Nitazoxanide

CAS: 55981-09-4

Nitazoxanide is a prodrug that is converted to the active form, nitazoxanide triacetate, in the stomach. It inhibits the growth of infectious agents by preventing their synthesis of DNA, RNA, or protein. Nitazoxanide has been shown to be effective against persistent strains of influenza A (H1N1) and A (H3N2) as well as rotavirus. It also has been shown to have a low toxicity profile in human clinical trials. Nitazoxanide is not an anti-inflammatory agent and does not inhibit cyclooxygenase enzymes. The drug can potentially be used for treatment of cancer due to its ability to inhibit mitochondrial membrane potential, which may lead to cell death.

Formula: C₁₂H₉N₃O₅S

Purity: Min. 98 Area-%

Color and Shape: White Slightly Yellow Powder

Molecular weight: 307.28 g/mol

Ref: 3D-FN26229

Nitazoxanide

CAS: 55981-09-4

Formula: C₁₂H₉N₃O₅S

Purity: 95.0%

Color and Shape: Crystalline Powder,Powder

Molecular weight: 307.28

Ref: 10-F076695