CAS 560-54-3

Strophanthidol

Description:

Strophanthidol is a cardiac glycoside derived from the seeds of the Strophanthus genus, particularly Strophanthus gratus. It is characterized by its ability to inhibit the Na+/K+ ATPase enzyme, which leads to increased intracellular sodium and calcium concentrations, ultimately enhancing cardiac contractility. This compound exhibits a structure that includes a steroid nucleus with a sugar moiety, contributing to its biological activity. Strophanthidol is known for its potential therapeutic effects in treating heart conditions, although its use is limited due to toxicity and the availability of safer alternatives. The substance is typically administered in a controlled manner, as it can lead to significant side effects, including arrhythmias and gastrointestinal disturbances. In laboratory settings, it is often utilized in research to study cardiac function and the mechanisms of glycoside action. As with many cardiac glycosides, careful consideration of dosage and patient monitoring is essential to mitigate risks associated with its pharmacological effects.

Formula: C₂₃H₃₄O₆

InChI: InChI=1/C23H34O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,15-18,24-25,27-28H,2-9,11-13H2,1H3/t15-,16+,17-,18+,20+,21-,22-,23-/m0/s1

InChI key: InChIKey=ZNDMLUUNNNHNKC-HZXDTFASSA-N

SMILES: C(O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C5=CC(=O)OC5)(CC[C@]1(O)C[C@@H](O)CC2)[H])[H]

Synonyms:

• (3Beta,5Beta)-3,5,14,19-Tetrahydroxycard-20(22)-Enolide
• (3Beta,5Beta,8Xi,9Xi)-3,5,14,19-Tetrahydroxycard-20(22)-Enolide
• (3β,5β)-3,5,14,19-Tetrahydroxycard-20(22)-enolide
• 5β-Card-20(22)-enolide, 3β,5,14,19-tetrahydroxy-
• Card-20(22)-enolide, 3,5,14,19-tetrahydroxy-, (3β,5β)-
• NSC 87314
• k-Strophanthidol
• Strophanthidol
• 5β,20(22)-Cardenolide-3β,5,14,19-tetrol
• STERIGMATOCYSTIN(RG)
• 3β,5,14,19-Tetrahydroxy-5β,20(22)-cardenolide
• 3β,5,14,19-Tetrahydroxy-5β,20(22)-cardenolide, 5β,20(22)-Cardenolide-3β,5,14,19-tetrol, K-Strophanthidol
• 3β,5β,14,19-Tetrahydroxy-5β-card-20(22)-enolide
• 3β,5,14,19-Tetrahydroxy-5β-card-20(22)-enolide
• 3,5,14,19-tetrahydroxy-,(3-beta,5-beta)-card-20(22)-enolid
• 3BETA,5,14,19-TETRAHYDROXY-5BETA,20[22]-CARDENOLIDE
• 3-beta,5,14,19-tetrahydroxy-5-beta-card-20(22)-enolid
• STROPHANTHIDOL(RG)

Strophanthidol

CAS: 560-54-3

Formula: C₂₃H₃₄O₆

Molecular weight: 406.52

Ref: 4Z-S-269005

Strophanthidol

Controlled Product

CAS: 560-54-3

Applications Strophanthidol is a natural compound, used in treating heart failure.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References O'Rourke, B., et al.: U.S., (2014); Thum, T., et al.: PCT Int. Appl., (2018);

Formula: C₂₃H₃₄O₆

Color and Shape: Neat

Molecular weight: 406.51

Ref: TR-S560540