CAS 560130-42-9

Vancomycin, N3′′-[2-(decylamino)ethyl]-29-[[(phosphonomethyl)amino]methyl]-, hydrochloride (1:1)

Description:

Vancomycin, N3′′-[2-(decylamino)ethyl]-29-[[(phosphonomethyl)amino]methyl]-, hydrochloride (1:1) is a synthetic derivative of the glycopeptide antibiotic vancomycin, which is primarily used to treat serious bacterial infections, particularly those caused by Gram-positive bacteria. This compound features a complex structure that includes a decylamino side chain and a phosphonomethyl group, which may enhance its antibacterial activity or alter its pharmacokinetic properties. The hydrochloride form indicates that it is a salt, which can improve solubility and stability in aqueous solutions. The presence of the phosphonomethyl group suggests potential for increased interaction with bacterial cell wall synthesis, a common mechanism of action for antibiotics. As with many antibiotics, the efficacy and safety profile of this compound would be evaluated through clinical studies, focusing on its spectrum of activity, resistance patterns, and potential side effects. Overall, this compound represents a modification of a well-established antibiotic, aiming to improve therapeutic outcomes against resistant bacterial strains.

Formula: C₈₀H₁₀₆Cl₂N₁₁O₂₇P·HCl

InChI: InChI=1S/C80H106Cl2N11O27P.ClH/c1-7-8-9-10-11-12-13-14-21-85-22-23-87-80(5)32-57(115-37(4)71(80)103)119-70-68(102)67(101)55(34-94)118-79(70)120-69-53-28-41-29-54(69)117-52-20-17-40(27-46(52)82)65(99)63-77(109)91-61(78(110)111)43-30-50(96)44(33-86-35-121(112,113)114)66(100)58(43)42-25-38(15-18-49(42)95)59(74(106)93-63)90-75(107)60(41)89-73(105)48(31-56(83)97)88-76(108)62(92-72(104)47(84-6)24-36(2)3)64(98)39-16-19-51(116-53)45(81)26-39;/h15-20,25-30,36-37,47-48,55,57,59-65,67-68,70-71,79,84-87,94-96,98-103H,7-14,21-24,31-35H2,1-6H3,(H2,83,97)(H,88,108)(H,89,105)(H,90,107)(H,91,109)(H,92,104)(H,93,106)(H,110,111)(H2,112,113,114);1H/t37-,47+,48-,55+,57-,59+,60+,61-,62+,63-,64+,65+,67+,68-,70+,71+,79-,80-;/m0./s1

InChI key: InChIKey=GSSIWSIRBWAZHG-ACOPVEIWSA-N

SMILES: O(C=1C2=CC3=CC1OC=4C(Cl)=CC(=CC4)[C@@H](O)[C@@H](NC([C@@H](CC(C)C)NC)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@]3(C(=O)N[C@@]5(C=6C=C(C=7C([C@@H](C(O)=O)NC(=O)[C@]([C@H](O)C=8C=C(Cl)C(O2)=CC8)(NC5=O)[H])=CC(O)=C(CNCP(=O)(O)O)C7O)C(O)=CC6)[H])[H])[C@H]9[C@H](O[C@H]%10C[C@@](NCCNCCCCCCCCCC)(C)[C@H](O)[C@H](C)O%10)[C@@H](O)[C@H](O)[C@@H](CO)O9.Cl

Synonyms:

• (3S,6R,7R,22R,23S,26S,36R,38aR)-3-(2-Amino-2-oxoethyl)-10,19-dichloro-44-((2-O-(3-((2-(decylamino)ethyl)amino)-3-C-methyl-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl)oxy)-7,22,28,30,32-pentahydroxy-6-(((2R)-4-methyl-2-(methylamino)pentanoyl)amino)-2,5,24,38,39-pentaoxo-29-(((phosphonomethyl)amino)methyl)-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-8,11:18,21-dietheno-23,36-(iminomethano)-22H-13,16:31,35-dimetheno-1H,13H-(1,6,9)oxadiazacyclohexadecino(4,5-m)(10,2,16)benzoxadiazacyclotetracosine-26-carboxylic acid monohydrochloride
• Td 6424
• Unii-0701472Zg0
• Vancomycin, N3'-(2-(decylamino)ethyl)-29-(((phosphonomethyl)amino)methyl)-, monohydrochloride
• Vancomycin, N^3′′-[2-(decylamino)ethyl]-29-[[(phosphonomethyl)amino]methyl]-, hydrochloride (1:1)
• Vancomycin, N^3′′-[2-(decylamino)ethyl]-29-[[(phosphonomethyl)amino]methyl]-, monohydrochloride
• Vibativ
• Vancomycin, N3′′-[2-(decylamino)ethyl]-29-[[(phosphonomethyl)amino]methyl]-, hydrochloride (1:1)
• Telavancin hydrochloride
• Telavancin HCl
• PubChem ID: 9812715
• TelavancinHydrochlorid
• N3''-[2-(Decylamino)ethyl]-29-[[(phosphonomethyl)amino]methyl]vancomycin hydrochloride

Telavancin DiHCl

CAS: 560130-42-9

Formula: C₈₀H₁₀₆Cl₂N₁₁O₂₇P·2HCl

Molecular weight: 1755.65 2*36.46

Ref: 4Z-T-284001

Telavancin HCl

CAS: 560130-42-9

Telavancin HCl is a lipoglycopeptide antibiotic with action on bacterial cell wall synthesis and membrane integrity and is used for treating complicated skin infections and hospital-acquired pneumonia caused by gram-positive bacteria.

Formula: C₈₀H₁₀₆Cl₂N₁₁O₂₇P·HCl

Purity: (%) Min. 92%

Color and Shape: White Powder

Molecular weight: 1,792.1 g/mol

Ref: 3D-AT76368