CAS 56049-88-8

(±)-Indacrinone

Description:

(±)-Indacrinone is a synthetic organic compound characterized by its unique structure, which includes a chromone core fused with a phenyl group. It is primarily recognized for its role as a diuretic agent, functioning by inhibiting the reabsorption of sodium and chloride in the renal tubules, thereby promoting increased urine output. This compound exhibits a moderate to high solubility in organic solvents, while its solubility in water is relatively low, which influences its bioavailability and pharmacokinetics. The compound has a chiral center, resulting in two enantiomers, which may exhibit different biological activities. (±)-Indacrinone has been studied for its potential therapeutic applications beyond diuresis, including its effects on cardiovascular health. Its chemical stability and reactivity are influenced by the presence of functional groups, making it a subject of interest in medicinal chemistry. Safety and handling precautions are essential due to its pharmacological properties, and it is typically handled in controlled laboratory environments.

Formula: C₁₈H₁₄Cl₂O₄

InChI: InChI=1S/C18H14Cl2O4/c1-18(11-5-3-2-4-6-11)8-10-7-12(24-9-13(21)22)15(19)16(20)14(10)17(18)23/h2-7H,8-9H2,1H3,(H,21,22)

InChI key: InChIKey=PRKWVSHZYDOZLP-UHFFFAOYSA-N

SMILES: O=C1C=2C(CC1(C)C3=CC=CC=C3)=CC(OCC(O)=O)=C(Cl)C2Cl

Synonyms:

• (±)-Indacrinone
• 1-Oxo-2-methyl-2-phenyl-6,7-dichloro-5-indanyloxyacetic acid
• 2,3-dihydro-1H-inden-1-one
• 2-[(6,7-Dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]acetic acid
• 6,7-Dichloro-2-methyl-1-oxo-2-phenyl-5-indanyloxyacetic acid
• Acetic acid, 2-[(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]-
• Acetic acid, [(6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy]-
• Indacrinic acid
• Indacrynic acid
• Indanone
• Indanone (pharmaceutical)
• Mk 196
• [(6,7-dichloro-2-methyl-1-oxo-2-phenyl-2,3-dihydro-1H-inden-5-yl)oxy]acetic acid

Indacrinone

CAS: 56049-88-8

Indacrinone is an investigational diuretic.

Formula: C₁₈H₁₄Cl₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 365.21

Ref: TM-T19430