CAS 561-65-9

18-Hydroxycorticosterone

Description:

18-Hydroxycorticosterone is a steroid hormone that plays a significant role in the regulation of electrolyte balance and blood pressure. It is a mineralocorticoid, primarily produced in the adrenal cortex, and is involved in the biosynthesis of aldosterone. This compound is characterized by its hydroxyl group at the 18th carbon position, which distinguishes it from other corticosteroids. It has a molecular formula that reflects its steroid structure, consisting of four fused carbon rings. The substance is typically found in small quantities in the human body and is important for maintaining sodium and potassium homeostasis. Its synthesis is regulated by the renin-angiotensin system and is influenced by various physiological conditions. In clinical settings, measuring levels of 18-hydroxycorticosterone can provide insights into adrenal function and disorders such as primary hyperaldosteronism. Due to its biological significance, it is also a subject of research in endocrinology and pharmacology.

Formula: C₂₁H₃₀O₅

InChI: InChI=1S/C21H30O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,14-17,19,22-23,25H,2-7,9-11H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

InChI key: InChIKey=HFSXHZZDNDGLQN-ZVIOFETBSA-N

SMILES: C(O)[C@@]12[C@]([C@]3([C@]([C@@H](O)C1)([C@]4(C)C(CC3)=CC(=O)CC4)[H])[H])(CC[C@@H]2C(CO)=O)[H]

Synonyms:

• (11Beta)-11,18,21-Trihydroxypregn-4-Ene-3,20-Dione
• (11β)-11,18,21-Trihydroxypregn-4-ene-3,20-dione
• 11beta,18,21-Trihydroxypregn-4-ene-3,20-dione
• Pregn-4-ene-3,20-dione, 11,18,21-trihydroxy-, (11beta)-
• Pregn-4-ene-3,20-dione, 11,18,21-trihydroxy-, (11β)-
• Pregn-4-ene-3,20-dione, 11β,18,21-trihydroxy-
• MeSH ID: D015069
• 18-Hydroxycorticosterone

(8S,9S,10R,11S,13R,14S,17S)-11-Hydroxy-17-(2-hydroxyacetyl)-13-(hydroxymethyl)-10-methyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one

CAS: 561-65-9

Formula: C₂₁H₃₀O₅

Molecular weight: 362.4599

Ref: IN-DA00DCWG

18-Hydroxycorticosterone

CAS: 561-65-9

18-Hydroxycorticosterone is a corticosteroid and corticosterone derivative, which can lead to serious electrolyte imbalances.

Formula: C₂₁H₃₀O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 362.46

Ref: TM-T19614

18-Hydroxy Corticosterone

CAS: 561-65-9

Formula: C₂₁H₃₀O₅

Molecular weight: 362.47

Ref: 4Z-C-10414

18-Hydroxy Corticosterone

Controlled Product

CAS: 561-65-9

Applications 18-Hydroxycorticosterone is a derivative of Corticosterone. 18-Hydroxycorticosterone is used as an intermediate in the synthesis of Aldosterone (A514700).
References Mulatero, P., et al.: J. Clin. Endocrinol. Metab., 83, 3996 (1998); Funder, J., et al.: J. Clin. Endocrinol. Metab., 93, 3266 (2008); Mulatero, P., et al.: Horm. Metab. Res., 2010, 42, 406 (2010);

Formula: C₂₁H₃₀O₅

Color and Shape: Neat

Molecular weight: 362.20932

Ref: TR-H824960

18-Hydroxycorticosterone

Controlled Product

CAS: 561-65-9

18-Hydroxycorticosterone is a hormone that is produced by the adrenal gland. It has been used as a marker for diagnosis of dopamine, physiological function, polymerase chain, metabolic disorders, and aldosterone levels. 18-Hydroxycorticosterone has also been used as an immunogen to produce monoclonal antibodies against this hormone. Soybean trypsin can be used to hydrolyze 18-hydroxycorticosterone into its two constituent parts, 18-hydroxycortisol and cortisone. Serum prolactin levels can be measured to confirm the diagnosis of adrenocortical carcinoma.

Formula: C₂₁H₃₀O₅

Purity: Min. 95%

Molecular weight: 362.46 g/mol

Ref: 3D-FH08456

18-Hydroxy Corticosterone

CAS: 561-65-9

Formula: C₂₁H₃₀O₅

Molecular weight: 362.46

Ref: ST-EA-CP-A321009