CAS 5611-51-8

Triamcinolone hexacetonide

Description:

Triamcinolone hexacetonide is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is derived from triamcinolone, a well-known glucocorticoid, and is characterized by its hexacetonide esterification, which enhances its lipophilicity and prolongs its action. This compound is typically administered via intramuscular injection or as an intra-articular injection for the treatment of various inflammatory conditions, including arthritis and other joint disorders. Triamcinolone hexacetonide exhibits a high affinity for glucocorticoid receptors, leading to the modulation of gene expression and subsequent reduction of inflammatory mediators. Its pharmacological effects include the inhibition of leukocyte infiltration at the site of inflammation, suppression of humoral immune responses, and stabilization of lysosomal membranes. While effective in managing inflammation, it may also have side effects, such as potential adrenal suppression and metabolic alterations, particularly with prolonged use. As with all corticosteroids, careful consideration of dosage and duration of therapy is essential to minimize adverse effects while maximizing therapeutic benefits.

Formula: C₃₀H₄₁FO₇

InChI: InChI=1/C30H41FO7/c1-25(2,3)15-24(35)36-16-22(34)30-23(37-26(4,5)38-30)13-20-19-9-8-17-12-18(32)10-11-27(17,6)29(19,31)21(33)14-28(20,30)7/h10-12,19-21,23,33H,8-9,13-16H2,1-7H3/t19-,20-,21-,23+,27-,28-,29-,30+/m0/s1

InChI key: InChIKey=TZIZWYVVGLXXFV-FLRHRWPCSA-N

SMILES: C(COC(CC(C)(C)C)=O)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C(CC4)=CC(=O)C=C5)[H])[H]

Synonyms:

• (11β,16α)-21-(3,3-Dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
• 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl 3,3-dimethylbutanoate
• Aristospan
• Butyric acid, 3,3-dimethyl-, 21-ester with 9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone
• Cl 34433
• Hexatrione
• Lederlon
• Lederspan
• Pregna-1,4-diene-3,20-dione, 21-(3,3-dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-(3,3-dimethylbutyrate)
• Tatba
• Triamcinolone Hexaacetonide
• Triamcinolone acetonide 21-tert-butylacetate
• Triamcinolone acetonide tert-butyl acetate
• Triamcinolone Hexacetonide (1679008)
• C08185
• 21-(3,3-Dimethyl-1-oxobutoxy)-9-fluoro-11β-hydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
• TRIAMCINOLONE HEXACETONIDE
• cl34433
• Triamcinolone hexatonide
• Triamcinolone hexacetonide CRS
• Triamcinolone Hexacetonide (200 mg)
• lic16,17-acetalwithacetone,21-(3,3-dimethylbutyrate)
• 4-diene-3,20-dione,9-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-pregna-cyc
• 9-Fluoro-11β,21-dihydroxy-16α,17-(isopropylidenebisoxy)pregna-1,4-diene-3,20-dione 21-(3,3-dimethylbutyrate)

Triamcinolone Hexacetonide

CAS: 5611-51-8

Color and Shape: Neat

Ref: 61-FOR0306.00

TRIAMCINOLONE HEXACETONIDE CRS

CAS: 5611-51-8

TRIAMCINOLONE HEXACETONIDE CRS

Formula: C₃₀H₄₁FO₇

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 532.6407

Ref: 41-T1950000

TRIAMCINOLONE HEXACETONIDE FOR SYSTEM SUITABILITY CRS

CAS: 5611-51-8

TRIAMCINOLONE HEXACETONIDE FOR SYSTEM SUITABILITY CRS

Formula: C₃₀H₄₁FO₇

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 532.6407

Ref: 41-Y0001843

Triamcinolone hexacetonide

CAS: 5611-51-8

Triamcinolone hexacetonide

Formula: C₃₀H₄₁FO₇

Purity: 99.6%

Color and Shape: White Crystalline Powder

Molecular weight: 532.28363

Ref: 47-680

Triamcinolone Hexacetonide

CAS: 5611-51-8

Halogenated derivatives of adrenal cortical hormones

Formula: C₃₀H₄₁FO₇

Color and Shape: Powder

Molecular weight: 532.28363

Ref: 45-1679008

Pregna-1,4-diene-3,20-dione,21-(3,3-dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a)-

CAS: 5611-51-8

Formula: C₃₀H₄₁FO₇

Purity: 98%

Color and Shape: Solid

Molecular weight: 532.6407

Ref: IN-DA01CCNK

Triamcinolone hexacetonide

CAS: 5611-51-8

Triamcinolone hexacetonide

Purity: ≥98%

Molecular weight: 532.64g/mol

Ref: 54-BUP09266

Triamcinolone Hexacetonide

Controlled Product

CAS: 5611-51-8

Formula: C₃₀H₄₁FO₇

Color and Shape: Neat

Molecular weight: 532.64

Ref: 86-MM0306.00

Triamcinolone hexacetonide

CAS: 5611-51-8

Formula: C₃₀H₄₁FO₇

Molecular weight: 532.65

Ref: 4Z-T-5326

Triamcinolone Hexacetonide-d9

CAS: 5611-51-8

Formula: C₃₀H₃₂D₉FO₇

Molecular weight: 541.70

Ref: 4Z-T-5332

Triamcinolone Hexacetonide

Controlled Product

CAS: 5611-51-8

Applications Triamcinolone Hexacetonide is the Intra-articular glucocorticoid treatment for rheumatoid arthritis.
References Abd-El-Barr, M.M., et al.: J. Ocul. Pharmacol. Ther., 24, 197 (2007); Eberhard, B.A., et al.: J. Rheumatol., 31, 2507 (2004);

Formula: C₃₀H₄₁FO₇

Color and Shape: White

Molecular weight: 532.64

Ref: TR-T767190

Triamcinolone hexacetonide

CAS: 5611-51-8

Triamcinolone hexacetonide, an exogenous synthetic corticosteroid, is a GR agonist used in the study of auto-reactive pericarditis and diabetic macular edema.

Formula: C₃₀H₄₁FO₇

Purity: 99.57%

Color and Shape: Solid

Molecular weight: 532.64

Ref: TM-T17162

Triamcinolone Hexacetonide-13CD3

Controlled Product

CAS: 5611-51-8

Formula: C₂₉CH₃₈D₃FO₇

Color and Shape: Neat

Molecular weight: 536.65

Ref: TR-T767194

Triamcinolone Hexacetonide-d9

Controlled Product

CAS: 5611-51-8

Applications Triamcinolone Hexacetonide-d9 is the labelled form of Triamcinolone Hexacetonide (T767190). Triamcinolone Hexacetonide is the Intra-articular glucocorticoid treatment for rheumatoid arthritis.
References Abd-El-Barr, M.M., et al.: J. Ocul. Pharmacol. Ther., 24, 197 (2007); Eberhard, B.A., et al.: J. Rheumatol., 31, 2507 (2004)

Formula: C₃₀D₉H₃₂FO₇

Color and Shape: Neat

Molecular weight: 541.696

Ref: TR-T767192

Triamcinolone hexacetonide

CAS: 5611-51-8

Triamcinolone hexacetonide is a nonsteroidal anti-inflammatory drug that is used to treat arthritis. It is a prodrug that is hydrolyzed in vivo to triamcinolone acetonide, its active form. Triamcinolone hexacetonide has been shown to be effective against arthritis and other inflammatory diseases of the joints. It inhibits the production of prostaglandins by blocking the release of arachidonic acid from membrane phospholipids. This reduces pain and inflammation with minimal side effects. The drug also has immunosuppressive properties, which may be due to its ability to inhibit toll-like receptor signaling pathways and response elements involved in the immune response. Triamcinolone hexacetonide can be administered orally or intra-articularly for treatment of inflammation.

Formula: C₃₀H₄₁FO₇

Purity: Min. 95%

Molecular weight: 532.64 g/mol

Ref: 3D-FAA61151