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CAS 56142-94-0

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1α,24R,25-Trihydroxyvitamin D3

Description:
1α,24R,25-Trihydroxyvitamin D3, also known as 1α,24R,25-trihydroxycholecalciferol, is a biologically active form of vitamin D3 that plays a crucial role in calcium and phosphate metabolism in the body. This compound is characterized by the presence of three hydroxyl (-OH) groups at the 1α, 24R, and 25 positions of the steroid structure, which enhances its solubility and biological activity. It is primarily involved in the regulation of gene expression related to calcium absorption in the intestines and bone mineralization. The substance is synthesized in the kidneys from its precursor, 25-hydroxyvitamin D3, and is known to have a significant impact on bone health and immune function. Its activity is mediated through the vitamin D receptor (VDR), influencing various physiological processes. Due to its role in maintaining calcium homeostasis, deficiencies or imbalances in this compound can lead to various health issues, including rickets in children and osteomalacia in adults.
Formula:C27H44O4
InChI:InChI=1S/C27H44O4/c1-17(8-13-25(30)26(3,4)31)22-11-12-23-19(7-6-14-27(22,23)5)9-10-20-15-21(28)16-24(29)18(20)2/h9-10,17,21-25,28-31H,2,6-8,11-16H2,1,3-5H3/b19-9+,20-10-/t17-,21-,22-,23+,24+,25-,27-/m1/s1
InChI key:InChIKey=WFZKUWGUJVKMHC-UKBUZQLGSA-N
SMILES:C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CC[C@H](C(C)(C)O)O)C)[H])[H]
Synonyms:
  • (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,4R)-4,5-Dihydroxy-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
  • (24R)-1a,24,25-Trihydroxyvitamin D3
  • (24R)-1α,24,25-Trihydroxyvitamin D<sub>3</sub>
  • (24R)-24-Hydroxycalcitriol
  • 1a,24R,25-Trihydroxycholecalciferol
  • 1a,24R,25-Trihydroxyvitamin D3
  • 1α,24R,25-Trihydroxyvitamin D<sub>3</sub>
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,24,25-tetrol, (1α,3β,5Z,7E,24R)-
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,24,25-tetrol,(1a,3b,5Z,7E,24R)- (9CI)
  • Pri 2193
  • See more synonyms
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