CAS 5624-35-1

nicotinamide guanine dinucleotide*sodium

Description:

Nicotinamide guanine dinucleotide sodium (often abbreviated as NGD or NADG) is a nucleotide derivative that plays a crucial role in various biochemical processes. It is a coenzyme involved in redox reactions, similar to its more widely known counterpart, nicotinamide adenine dinucleotide (NAD). NGD is characterized by its structure, which includes a nicotinamide moiety, a guanine base, and two phosphate groups, contributing to its function in cellular metabolism. The sodium salt form enhances its solubility in aqueous solutions, making it suitable for various laboratory applications. NGD is involved in cellular signaling and energy metabolism, and it may also play a role in the regulation of enzymatic activities. Its presence in biological systems is essential for maintaining cellular homeostasis and facilitating metabolic pathways. As a research chemical, it is utilized in studies related to enzymatic reactions, cellular signaling, and the investigation of metabolic disorders. Proper handling and storage conditions are necessary to maintain its stability and efficacy in experimental settings.

Formula: C₂₁H₂₈N₇O₁₅P₂

InChI: InChI=1/C21H27N7O15P2/c22-16(33)8-2-1-3-27(4-8)19-14(31)12(29)9(41-19)5-39-44(35,36)43-45(37,38)40-6-10-13(30)15(32)20(42-10)28-7-24-11-17(28)25-21(23)26-18(11)34/h1-4,7,9-10,12-15,19-20,29-32H,5-6H2,(H6-,22,23,25,26,33,34,35,36,37,38)/p+1

Synonyms:

• Nicotinamide guanine dinucleotide
• Ngd compound
• Guanosine 5'-(trihydrogen diphosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt
• [5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] hydrogen phosphate

Nicotinamide guanine dinucleotide sodium salt

CAS: 5624-35-1

Nicotinamide guanine dinucleotide sodium salt is a nucleoside that is the product of the reaction between nicotinamide and guanosine triphosphate. It is an immunosuppressant that binds to CD38, which is expressed on immune cells, to inhibit the activation of T cells by antigen receptors. Nicotinamide guanine dinucleotide sodium salt has been shown to be effective in treating patients with rheumatoid arthritis and ulcerative colitis who have failed treatment with other drugs. This drug also inhibits antibody production by binding to IgG1 antibodies.

Formula: C₂₁H₂₈N₇O₁₅P₂·xNa

Purity: Min. 95%

Color and Shape: Off-White To Yellow Solid

Molecular weight: 680.43 g/mol

Ref: 3D-NN46649