CAS 5630-53-5

Tibolone

Description:

Tibolone is a synthetic steroid with a chemical structure that mimics the effects of estrogen, progesterone, and testosterone, making it a unique compound in hormone therapy. It is primarily used in the management of menopausal symptoms, such as hot flashes and vaginal dryness, and is also indicated for the prevention of osteoporosis in postmenopausal women. Tibolone exhibits tissue-selective actions, meaning it can exert estrogenic effects on certain tissues, like bone and the vaginal epithelium, while having anti-estrogenic effects on others, such as breast tissue. Its mechanism of action involves binding to estrogen receptors, leading to various physiological responses. Tibolone is typically administered orally and has a favorable pharmacokinetic profile, with a relatively long half-life, allowing for once-daily dosing. Common side effects may include headaches, mood changes, and gastrointestinal disturbances. As with any hormone therapy, the use of tibolone should be carefully considered, weighing the benefits against potential risks, particularly in individuals with a history of hormone-sensitive conditions.

Formula: C₂₁H₂₈O₂

InChI: InChI=1S/C21H28O2/c1-4-21(23)10-8-18-19-13(2)11-14-12-15(22)5-6-16(14)17(19)7-9-20(18,21)3/h1,13,17-19,23H,5-12H2,2-3H3/t13-,17-,18+,19-,20+,21+/m1/s1

InChI key: InChIKey=WZDGZWOAQTVYBX-XOINTXKNSA-N

SMILES: C[C@H]1[C@]2([C@]3([C@@](C)([C@@](C#C)(O)CC3)CC[C@@]2(C4=C(C1)CC(=O)CC4)[H])[H])[H]

Synonyms:

• (7A,17A)-17-Hydroxy-7-Methyl-19-Norpregn-5(10)-En-20-Yl-3-One
• (7Alpha,17Beta)-17-Ethynyl-17-Hydroxy-7-Methylestr-5(10)-En-3-One
• (7Alpha,8Xi,13Xi,17Beta)-17-Ethynyl-17-Hydroxy-7-Methylestr-5(10)-En-3-One
• (7α,17α)-17-Hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one
• 17-Hydroxy-7Alpha-Methyl-19-Norpregn-5(10)-En-20-Yn-3-One
• 17Alpha-Hydroxy-7Alpha-Methyl-19-Norpregn-5(10)-En-20-Yn-3-One
• 19-Nor-17α-pregn-5(10)-en-20-yn-3-one, 17-hydroxy-7α-methyl-
• 19-Norpregn-5(10)-En-20-Yn-3-One,17-Hydroxy-7-Methyl-, (7A,17A)-
• 5(10)-Estren-7-Alpha-Methyl-17-Alpha-Ethynyl-17-Beta-Ol-3-One
• 7α-Methyl-17α-ethynyl-17β-hydroxy-5(10)-estren-3-one
• 7α-Methyl-Δ⁵,¹⁰-norethindrone
• Livial
• Liviella
• Org OD 14

Tibolone

Controlled Product

CAS: 5630-53-5

Color and Shape: Neat

Ref: 61-FOR1076.00

TIBOLONE CRS

CAS: 5630-53-5

TIBOLONE CRS

Ref: 41-Y0002348

TIBOLONE FOR SYSTEM SUITABILITY CRS

CAS: 5630-53-5

TIBOLONE FOR SYSTEM SUITABILITY CRS

Formula: C₂₁H₂₈O₂

Color and Shape: Crystalline Powder. White. Crystals. Powder.

Molecular weight: 312.4458

Ref: 41-Y0000668

Tibolone

CAS: 5630-53-5

Tibolone

Formula: C₂₁H₂₈O₂

Purity: 99.5%

Color and Shape: White

Molecular weight: 312.20893

Ref: 47-848

Tibolone impurity standard

CAS: 5630-53-5

Tibolone impurity standard

Color and Shape: White

Ref: 47-849

Tibolone

CAS: 5630-53-5

Formula: C₂₁H₂₈O₂

Molecular weight: 312.45

Ref: 7W-GP5472

Tibolone

CAS: 5630-53-5

Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the

Formula: C₂₁H₂₈O₂

Purity: 99.70% - 99.71%

Color and Shape: White To Off-White Crystalline Powder

Molecular weight: 312.45

Ref: TM-T4549

Tibolone

Controlled Product

CAS: 5630-53-5

Color and Shape: Neat

Ref: 86-MM1076.00

Tibolone

Controlled Product

CAS: 5630-53-5

Applications A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
References de Visser, J., et al.: Arzneim.-Forsch., 34, 1010 (1984), Geusens, P., et al.: Maturitas Suppl, 1, 1 (1987)

Formula: C₂₁H₂₈O₂

Color and Shape: White

Molecular weight: 312.45

Ref: TR-T437500

Tibolone

Controlled Product

CAS: 5630-53-5

Tibolone is a synthetic steroidal estrogen with both estrogenic and progestogenic activity. It has been shown to be effective in the treatment of postmenopausal symptoms, especially those related to the breast. Tibolone is also used for prevention of osteoporosis and to prevent recurrence of hormone-dependent cancers such as breast cancer or endometrial cancer. Tibolone binds to both estrogen receptor subtypes (ERα and ERβ) and progesterone receptor (PR), but with higher affinity for ERβ. This leads to increased levels of circulating estradiol and progesterone when compared to other estrogens such as nomegestrol acetate or conjugated equine estrogen. The drug also decreases expression of genes that are regulated by the response element (RE) in ERβ-positive cells, which may contribute to its anti-cancer effects. Tibolone has been shown to be statistically more effective than nomegestrol acetate in reducing hot flashes

Formula: C₂₁H₂₈O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 312.45 g/mol

Ref: 3D-FT35065

Tibolone (1 mg/ml in Acetonitrile)

Controlled Product

CAS: 5630-53-5

Formula: C₂₁H₂₈O₂

Color and Shape: Single Solution

Molecular weight: 312.45

Ref: TR-KIT7525