CAS 56391-57-2

Netilmicin sulfate

Description:

Netilmicin sulfate is an aminoglycoside antibiotic primarily used to treat serious infections caused by Gram-negative bacteria. It is derived from the natural antibiotic gentamicin and exhibits a broad spectrum of antibacterial activity. The compound is characterized by its ability to inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit, which disrupts the translation process. Netilmicin is particularly effective against various strains of Pseudomonas aeruginosa and Enterobacteriaceae. It is typically administered via injection, as it is poorly absorbed from the gastrointestinal tract. The sulfate form enhances its solubility in aqueous solutions, making it suitable for parenteral use. Common side effects may include nephrotoxicity and ototoxicity, which are associated with aminoglycosides. Due to its potential for resistance development, careful monitoring of bacterial susceptibility is essential when using netilmicin in clinical settings. Overall, netilmicin sulfate remains a valuable option in the treatment of severe infections, particularly in patients with compromised immune systems or those requiring hospitalization.

Formula: C₂₁H₄₁N₅O₇H₂O₄S

InChI: InChI=1S/C21H41N5O7.H2O4S/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20;1-5(2,3)4/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3;(H2,1,2,3,4)/t11-,12+,13-,14+,15-,16-,17+,18-,19-,20-,21+;/m1./s1

InChI key: InChIKey=PQHZSWZPVGHDEZ-UIQTUGNFSA-N

SMILES: O([C@H]1[C@H](NCC)C[C@H](N)[C@@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@@H]1O)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3.S(=O)(=O)(O)O

Synonyms:

• (1S,2S,3R,4S,6R)-4-amino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-6-(ethylamino)-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside sulfate (2:5)
• (1S,2S,3R,4S,6R)-4-amino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-6-(ethylamino)-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside sulfate (1:1)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-N¹-ethyl-, sulfate (2:5)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-N¹-ethyl-, sulfate (2:5) (salt)
• Certomycin
• Naitimixing
• Netiline
• Netillin
• Netilmicin Sulphate
• Netilmycin Sulphate
• Netilyn
• Netromicine
• Nettacin
• Vectacin
• Zetamicin
• Netilmicin sulfate
• D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-N1-ethyl-, sulfate (2:5)

Netilmicin sulfate, 595 ^mg/mg

CAS: 56391-57-2

A broad spectrum antibiotic

Formula: C₂₁H₄₁N₅O₇·5H₂SO₄

Molecular weight: 720.75

Ref: 02-J66302

FIRST INTERNATIONAL STANDARD FOR NETILMICIN

CAS: 56391-57-2

FIRST INTERNATIONAL STANDARD FOR NETILMICIN

Formula: C₄₂H₉₂N₁₀O₃₄S₅

Molecular weight: 1441.552

Ref: 41-ISA_83_577

NETILMICIN SULFATE CRS

CAS: 56391-57-2

NETILMICIN SULFATE CRS

Formula: C₄₂H₉₂N₁₀O₃₄S₅

Molecular weight: 1441.552

Ref: 41-N0559000

NETILMICIN SULFATE FOR LC ASSAY CRS

CAS: 56391-57-2

NETILMICIN SULFATE FOR LC ASSAY CRS

Formula: C₄₂H₉₂N₁₀O₃₄S₅

Molecular weight: 1441.552

Ref: 41-Y0001894

NETILMICIN FOR PEAK IDENTIFICATION CRS

CAS: 56391-57-2

NETILMICIN FOR PEAK IDENTIFICATION CRS

Formula: C₄₂H₉₂N₁₀O₃₄S₅

Molecular weight: 1441.552

Ref: 41-Y0001890

Netilmicin Sulfate

CAS: 56391-57-2

Antibiotics nesoi

Formula: (C₂₁H₄₁N₅O₇)₂·5H₂SO₄

Color and Shape: White Yellow Powder

Molecular weight: 1440.4381

Ref: 45-1460500

Netilmicin sulfate(2:5)

CAS: 56391-57-2

Formula: C₄₂H₉₂N₁₀O₃₄S₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 1441.5515

Ref: IN-DA00IMJA

Netilmicin sulfate

CAS: 56391-57-2

Netilmicin sulfate (Netromycin) is an aminoglycoside antibiotic.

Formula: C₂₁H₄₁N₅O₇H₂SO₄

Purity: 99.79% - 99.79%

Color and Shape: White To Off-White Powder

Molecular weight: 720.78

Ref: TM-T1036

Netilmicin sulfate salt

CAS: 56391-57-2

Formula: C₂₁H₄₁N₅O₇H₂SO₄

Purity: ≥ 595μg/mg (C21H41N5O7, dried basis)

Color and Shape: White to light-yellow powder

Molecular weight: 1441.5

Ref: 7W-GA1999

Netilmicin Sulfate

CAS: 56391-57-2

Netilmicin Sulfate

Purity: >98.0%

Ref: 54-OR1079031

Netilmicin Sulfate

CAS: 56391-56-1, 56391-57-2

Formula: C₂₁H₄₁N₅O₇H₂SO₄

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 720.77

Ref: 3B-N1108

Netilmicin Sulfate

CAS: 56391-57-2

Stability Hygroscopic
Applications Semisynthetic aminoglycoside antibiotic, related to sisomicin. Antibacterial.
References Miller, G.H., et al.: Antimicrob. Agents Chemother., 10, 827 (1976), Raab, W., et al.: Adv. Clin. Pharmacol., 15, 91 (1978), Noone, P., et al.: Drugs, 27, 548 (1984),

Formula: C₂₁H₄₁N₅O₇·5H₂O₄S

Color and Shape: Light Yellow

Molecular weight: 1441.55

Ref: TR-N390800

Netilmicin sulfate

CAS: 56391-57-2

Netilmicin sulfate is an aminoglycoside antibiotic with action on bacterial protein synthesis by binding to the 30S ribosomal subunit and is used for treating severe bacterial infections.

Formula: C₄₂H₉₂N₁₀O₃₄S₅

Purity: Min. 595 Ug/Mg

Color and Shape: Powder

Molecular weight: 1,441.56 g/mol

Ref: 3D-AN36889

Netilmicin Sulphate (NTC Sulphate), 595ug/mg

CAS: 56391-57-2

Formula: (C₂₁H₄₁N₅O₇)₂·5H₂SO₄

Color and Shape: White to pale yellow, Powder

Molecular weight: 1441.5

Ref: SR-60609

Netilmicin Sulfate

CAS: 56391-57-2

Formula: C₂₁H₄₁N₅O₇(H₂O₄S)

Molecular weight: 475.59 : 5/2(98.07)

Ref: ST-EA-CP-N94005