CAS 56392-16-6

α-Hydroxymetoprolol

Description:

α-Hydroxymetoprolol is a beta-blocker that is primarily used in the management of cardiovascular conditions, particularly hypertension and heart failure. It is a derivative of metoprolol, featuring a hydroxyl group at the alpha position of the side chain, which enhances its pharmacological properties. This compound exhibits selective antagonism of beta-1 adrenergic receptors, leading to decreased heart rate and myocardial contractility, thereby reducing cardiac workload and oxygen demand. In terms of physical characteristics, α-Hydroxymetoprolol is typically a white to off-white crystalline powder, which is soluble in water and organic solvents, facilitating its formulation in various pharmaceutical preparations. The compound's chemical structure contributes to its efficacy and safety profile, making it a valuable agent in treating cardiovascular diseases. As with other beta-blockers, it may have side effects, including fatigue, dizziness, and potential interactions with other medications, necessitating careful monitoring in clinical use.

Formula: C₁₅H₂₅NO₄

InChI: InChI=1S/C15H25NO4/c1-11(2)16-8-13(17)9-20-14-6-4-12(5-7-14)15(18)10-19-3/h4-7,11,13,15-18H,8-10H2,1-3H3

InChI key: InChIKey=OFRYBPCSEMMZHR-UHFFFAOYSA-N

SMILES: C(COC)(O)C1=CC=C(OCC(CNC(C)C)O)C=C1

Synonyms:

• 1-Isopropylamino-3-[4-(1-hydroxy-2-methoxyethyl)phenoxy]-2-propanol
• 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]-α-(methoxymethyl)benzenemethanol
• H 119/66
• a-Hydroxymetoprolol
• Benzenemethanol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-α-(methoxymethyl)-

α-Hydroxy Metoprolol

CAS: 56392-16-6

Formula: C₁₅H₂₅NO₄

Color and Shape: White To Off-White Solid

Molecular weight: 283.37

Ref: 4Z-M-081

(+/-)-α-Hydroxymetoprolol(unlabelled)

CAS: 56392-16-6

Color and Shape: Off-White Solid

Molecular weight: 283.37

Ref: 3U-X5681

α-Hydroxy Metoprolol (Mixture of Diastereomers)

Controlled Product

CAS: 56392-16-6

Applications A metabolite of Metoprolol.
References Lennard, M.S., et al.: Br. J. Clin. Pharmacol., 14, 713 (1982), Gengo, F.M., et al.: Clin. Pharmacol. Ther., 36, 320 (1984),

Formula: C₁₅H₂₅NO₄

Color and Shape: Off-White To Beige

Molecular weight: 283.36

Ref: TR-H948390

α-Hydroxy Metoprolol

CAS: 56392-16-6

Formula: C₁₅H₂₅NO₄

Molecular weight: 283.37

Ref: ST-EA-CP-M17059

α-hydroxy Metoprolol

CAS: 56392-16-6

α-hydroxy Metoprolol is an active metabolite of the β1-adrenergic receptor blocker metoprolol.

Formula: C₁₅H₂₅NO₄

Color and Shape: Solid

Molecular weight: 283.36

Ref: TM-T69094