CAS 565-20-8

Monoacetyldapsone

Description:

Monoacetyldapsone, with the CAS number 565-20-8, is a chemical compound that belongs to the class of sulfonamides, which are known for their antibacterial properties. It is a derivative of dapsone, featuring an acetyl group that enhances its pharmacological profile. This compound typically appears as a white to off-white crystalline powder and is soluble in organic solvents such as ethanol and dimethyl sulfoxide, but has limited solubility in water. Monoacetyldapsone exhibits antimicrobial activity, particularly against certain bacteria, making it relevant in the treatment of various infections, including those caused by Mycobacterium leprae, the causative agent of leprosy. The compound's mechanism of action involves the inhibition of folate synthesis in bacteria, which is crucial for their growth and replication. Additionally, it may have anti-inflammatory properties, contributing to its therapeutic applications. As with many sulfonamides, caution is advised regarding potential allergic reactions and side effects, which can include skin rashes and hematological issues.

Formula: C₁₄H₁₄N₂O₃S

InChI: InChI=1S/C14H14N2O3S/c1-10(17)16-12-4-8-14(9-5-12)20(18,19)13-6-2-11(15)3-7-13/h2-9H,15H2,1H3,(H,16,17)

InChI key: InChIKey=WDOCBIHNYYQINH-UHFFFAOYSA-N

SMILES: S(=O)(=O)(C1=CC=C(NC(C)=O)C=C1)C2=CC=C(N)C=C2

Synonyms:

• 4'-Sulfanilylacetanilide
• 4-Acetamido-4′-aminodiphenyl sulfone
• 4-Acetamidophenyl 4′-aminophenyl sulfone
• 4-Acetylamino-4′-aminodiphenyl sulfone
• 4-Acetylamino-4′-aminophenyl sulfone
• 4-Amino-4′-acetamidodiphenyl sulfone
• Acetamide, N-(4-((4-aminophenyl)sulfonyl)phenyl)-
• Acetamide, N-(4-((4-aminophenyl)sulfonyl)phenyl)- (9CI)
• Acetanilide, 4'-sulfanilyl-
• Acetyldapsone
• Brn 2746651
• Ccris 5693
• Madds
• Monoacetyldapsone
• N-(4-((4-Aminophenyl)sulfonyl)phenyl)acetamide
• N-Acetyl-4,4'-diaminodiphenylsulfone
• N-Acetyldapsone
• Nsc 27184
• 3-13-00-01286 (Beilstein Handbook Reference)
• n-(4-((4-aminophenyl)sulfonyl)phenyl)-acetamid
• N-Acetyl[4,4'-sulfonylbis(aniline)]
• ACETYL DAPSONE
• 4’-sulfanilyl-acetanilid
• N-acetyle Dapsone D8
• Dapsone N-Acetyl Impurity/ Monoacetyl Dapsone
• N-Acetyldapsone solution in Methanol, 1000ug/mL
• N-Acetyldapsone, MADDS
• MONO-N-ACETYL-4,4'-SULFONYLBISBENZENEAMINE
• Monoacetyldapson
• Dapsone N-Acetyl Impurity
• N-MONOACETYL-4,4'-DIAMINODIPHENYL SULFONE
• MONOACETYL DAPSONE
• Dapsone Impurity 2（Monoacetyl Dapsone）

4-(Acetamido)-4'-aminobiphenyl sulphone

CAS: 565-20-8

4-(Acetamido)-4'-aminobiphenyl sulphone

Purity: ≥95%

Molecular weight: 290.34g/mol

Ref: 54-OR59798

N-acetyl Dapsone

CAS: 565-20-8

N-acetyl Dapsone

Purity: ≥98%

Molecular weight: 290.34g/mol

Ref: 54-BUP02565

Monoacetyl Dapsone

CAS: 565-20-8

Formula: C₁₄H₁₄N₂O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 290.34

Ref: 4Z-D-013

Monoacetyldapsone

CAS: 565-20-8

Formula: C₁₄H₁₄N₂O₃S

Molecular weight: 290.34

Ref: 7W-GL4738

N-acetyl Dapsone

CAS: 565-20-8

N-acetyl Dapsone is an anti-inflammatory and antimicrobial compound widely used in the treatment of leprosy, malaria, acne and various immune disorders.

Formula: C₁₄H₁₄N₂O₃S

Purity: 99.83%

Color and Shape: White

Molecular weight: 290.34

Ref: TM-T35903

N-Acetyldapsone

CAS: 565-20-8

Formula: C₁₄H₁₄N₂O₃S

Color and Shape: Neat

Molecular weight: 290.34

Ref: 04-C10023200

N-Acetyl Dapsone

Controlled Product

CAS: 565-20-8

Applications A metabolite of Dapsone (D193250).
References Shin, I., et al.: J. App. Pharmacol., 10, 193 (2002), Bhaiya, P., et al.: Toxicol. App. Pharmacol., 215, 158 (2006), Paixao, P., et al.: Eur. J. Pharm. Sci., 36, 544 (2009),

Formula: C₁₄H₁₄N₂O₃S

Color and Shape: Neat

Molecular weight: 290.34

Ref: TR-A168435

N-Acetyl Dapsone-d4

Controlled Product

CAS: 565-20-8

Formula: C₁₄D₄H₁₀N₂O₃S

Color and Shape: Neat

Molecular weight: 294.362

Ref: TR-A168436

N-Acetyl Dapsone

CAS: 565-20-8

Formula: C₁₄H₁₄N₂O₃S

Molecular weight: 290.3

Ref: ST-EA-CP-D10007

N-Acetyl dapsone

CAS: 565-20-8

N-Acetyl dapsone is a drug used to treat metabolic disorders. It is a structural analog of dapsone that has the same mechanism of action and therapeutic use, but with fewer side effects. N-Acetyl dapsone is converted by oxidation in the liver to dapsone, which inhibits the activity of a number of enzymes, including dehydrogenases and monoamine oxidases. The activity index for N-acetyl dapsone is 1.5 times that for dapsone. The binding constants for N-acetyl dapsone are higher than those for dapsone and have been shown to be more selective for human serum albumin than for rat liver microsomes. In addition, N-acetyl dapsone does not bind to lysine residues on proteins as well as does its parent compound, which may explain its lower incidence of side effects such as agranulocytosis and methemoglobinemia in humans compared

Formula: C₁₄H₁₄N₂O₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 290.34 g/mol

Ref: 3D-FA17014