CAS 56518-41-3

Brodimoprim

Description:

Brodimoprim is a synthetic antimicrobial agent primarily used for its antibacterial properties. It belongs to the class of compounds known as diaminopyrimidines, which function by inhibiting bacterial dihydrofolate reductase, an enzyme critical for folate synthesis and, consequently, nucleic acid production in bacteria. This mechanism makes Brodimoprim effective against a range of gram-positive and gram-negative bacteria. The substance is characterized by its relatively low solubility in water, which can influence its bioavailability and pharmacokinetics. Brodimoprim is often utilized in veterinary medicine, particularly for treating urinary tract infections in animals. Its safety profile indicates that it has a low toxicity level when used as directed, although potential side effects may include gastrointestinal disturbances or allergic reactions in sensitive individuals. As with any antimicrobial agent, the development of resistance is a concern, necessitating careful consideration of its use in clinical settings. Overall, Brodimoprim represents a valuable tool in the arsenal against bacterial infections, particularly in veterinary applications.

Formula: C₁₃H₁₅BrN₄O₂

InChI: InChI=1S/C13H15BrN4O2/c1-19-9-4-7(5-10(20-2)11(9)14)3-8-6-17-13(16)18-12(8)15/h4-6H,3H2,1-2H3,(H4,15,16,17,18)

InChI key: InChIKey=BFCRRLMMHNLSCP-UHFFFAOYSA-N

SMILES: C(C1=CC(OC)=C(Br)C(OC)=C1)C=2C(N)=NC(N)=NC2

Synonyms:

• (2,4-Diamino-5-(4-Bromo-3,5-Dimethoxybenzylpyrimidine)
• 2,4-Diamino-5-(4-Bromo-3,5-Dimethoxybenzyl) Pyrimidine
• 2,4-Pyrimidinediamine, 5-[(4-Bromo-3,5-Dimethoxyphenyl)Methyl]-
• 260-238-8
• 5-(4-Bromo-3,5-Dimethoxybenzyl)Pyrimidine-2,4-Diamine
• 5-[(4-Bromo-3,5-dimethoxyphenyl)methyl]-2,4-pyrimidinediamine
• 56518-41-3
• Hyprim
• Ro 10-5970
• Ro 105970
• Unitrim

2,4-Pyrimidinediamine, 5-[(4-bromo-3,5-dimethoxyphenyl)methyl]-

CAS: 56518-41-3

Formula: C₁₃H₁₅BrN₄O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 339.1878

Ref: IN-DA01CCA2

Brodimoprim

CAS: 56518-41-3

Formula: C₁₃H₁₅BrN₄O₂

Molecular weight: 339.19

Ref: 7W-GP3609

Brodimoprim

CAS: 56518-41-3

Brodimoprim

Purity: ≥98%

Molecular weight: 339.19g/mol

Ref: 54-BUP07203

Brodimoprim

Controlled Product

CAS: 56518-41-3

Applications A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent.
References Thomson, C.J. et al.: J. Chemother., 5, 458 (1993); Hawserl, S. et al.: Biochem. Pharmacol., 71, 941 (2006); Conforti, A. et al.: Br. J. Clin. Pharmacol., 44, 411 (1997);

Formula: C₁₃H₁₅BrN₄O₂

Color and Shape: Neat

Molecular weight: 339.19

Ref: TR-B678100

Brodimoprim

CAS: 56518-41-3

Brodimoprim is a synthetic analog of trimethoprim, an antimicrobial agent used to treat various infectious diseases. Brodimoprim is a prodrug that is converted to trimethoprim in the body. Brodimoprim is effective against infections caused by bacteria that are resistant to other antibiotics and it has been shown to be safe for use in humans. Brodimoprim binds to bacterial DNA gyrase, inhibiting bacterial cell division and growth. This drug also has anti-inflammatory properties and can be used as a treatment for inflammatory bowel disease.

Formula: C₁₃H₁₅BrN₄O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 339.19 g/mol

Ref: 3D-FB19014

Brodimoprim

CAS: 56518-41-3

Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR).

Formula: C₁₃H₁₅BrN₄O₂

Purity: 98% - 99.71%

Color and Shape: Solid

Molecular weight: 339.19

Ref: TM-T19858