CAS 56585-33-2
:Trimethoprim sulfate
Description:
Trimethoprim sulfate is a synthetic antibiotic primarily used to treat bacterial infections, particularly urinary tract infections. It is a dihydrofolate reductase inhibitor, which disrupts the bacterial folate synthesis, ultimately hindering DNA synthesis and bacterial growth. The compound is characterized by its solubility in water, which facilitates its administration in various formulations, including oral tablets and injectable solutions. Trimethoprim sulfate is often combined with sulfamethoxazole, a sulfonamide antibiotic, to enhance its antibacterial efficacy through a synergistic effect. The substance is generally well-tolerated, though it may cause side effects such as gastrointestinal disturbances, skin rashes, and, in rare cases, hematological reactions. Its pharmacokinetics involve rapid absorption and distribution, with a half-life that allows for convenient dosing schedules. Trimethoprim sulfate is classified under the World Health Organization's List of Essential Medicines, highlighting its importance in treating common infections. As with all antibiotics, appropriate use is crucial to prevent the development of resistance.
Formula:C14H18N4O3H2O4S
InChI:InChI=1S/C14H18N4O3.H2O4S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-5(2,3)4/h5-7H,4H2,1-3H3,(H4,15,16,17,18);(H2,1,2,3,4)
InChI key:InChIKey=GSKPSSNZVPYRCH-UHFFFAOYSA-N
SMILES:S(=O)(=O)(O)O.C(C1=CC(OC)=C(OC)C(OC)=C1)C=2C(N)=NC(N)=NC2
Synonyms:- 2,4-Pyrimidinediamine, 5-[(3,4,5-trimethoxyphenyl)methyl]-, sulfate (2:1)
- Trimethoprim sulfate
- Trimethoprim hemisulfate
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Found 2 products.
Trimethoprim sulfate
CAS:Formula:C28H38N8O10SPurity:≥ 99.0%Color and Shape:White powderMolecular weight:678.7Trimethoprim sulfate
CAS:Trimethoprim sulfate, a dihydrofolate reductase inhibitor, treats bacterial infections and sometimes malaria; may depress hematopoiesis.Formula:C28H38N8O10SColor and Shape:SolidMolecular weight:678.72
