CAS 56586-95-9

cyclo(his-phe)

Description:

Cyclo(his-phe), also known as cyclo(histidyl-phenylalanine), is a cyclic dipeptide composed of the amino acids histidine and phenylalanine. This compound features a cyclic structure formed by the peptide bond between the carboxyl group of histidine and the amino group of phenylalanine, resulting in a stable ring formation. Cyclo(his-phe) exhibits characteristics typical of peptides, including the ability to participate in hydrogen bonding and interactions with other biomolecules, which can influence its biological activity. The presence of the imidazole side chain from histidine allows for potential coordination with metal ions, while the aromatic side chain from phenylalanine contributes to hydrophobic interactions. This compound may exhibit various biological activities, including antioxidant properties and potential roles in signaling pathways. Its unique structure and properties make cyclo(his-phe) of interest in biochemical research and potential therapeutic applications. As with many peptides, its stability and solubility can be influenced by environmental factors such as pH and temperature.

Formula: C₁₅H₁₆N₄O₂

Synonyms:

• Cyclo(-His-Phe)

Cyclo(-His-Phe)

CAS: 56586-95-9

Catalyst for asymmetric cyanohydrin synthesis. The addition of hydrogen cyanide to benzaldehyde gives the highest optical yield ever obtained for the corresponding cyanohydrin. In a study of McCleland et al., Cyclo(His-Phe) showed significant anti-tumour activity, causing reduction of cell viability in cervical cancer cells. In isolated rat hearts, the diketopiperazine caused a gradual reduction of heart rate and a decrease in coronary flow rate.

Formula: C₁₅H₁₆N₄O₂

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 284.32

Ref: 01-4006752

Cyclo(-His-Phe)

Controlled Product

CAS: 56586-95-9

Formula: C₁₅H₁₆N₄O₂

Color and Shape: Neat

Molecular weight: 284.313

Ref: TR-C996108

Cyclo(-His-Phe)

CAS: 56586-95-9

Cyclo(His-Phe) is a cyclic dipeptide that is used as an analytical reagent for the LC-MS/MS analysis of cyclic peptides. The cyclic dipeptide is synthesized by reacting the amino acid His with the amino acid Phe in DMSO, yielding a mixture of products. The composition of Cyclo(His-Phe) can be determined by LC-MS/MS analysis. This compound is bioactive and has been shown to have antioxidant properties as well as anti-inflammatory effects in mice.

Formula: C₁₅H₁₆N₄O₂

Purity: Min. 95%

Molecular weight: 284.31 g/mol

Ref: 3D-FC108012