CAS 56588-58-0

Estra-1,3,5(10)-trien-17-one-16,16-d2,3-hydroxy- (9CI)

Description:

Estra-1,3,5(10)-trien-17-one-16,16-d2,3-hydroxy- (9CI), with the CAS number 56588-58-0, is a synthetic steroid compound that belongs to the class of estrogens. This compound features a triene structure, which is characterized by three conjugated double bonds, contributing to its stability and reactivity. The presence of a ketone group at the 17-position and a hydroxyl group at the 3-position are significant for its biological activity, influencing its interaction with estrogen receptors. The deuterated positions at 16,16-d2 indicate that hydrogen atoms at these positions are replaced with deuterium, which can affect the compound's metabolic stability and pharmacokinetics. Estra-1,3,5(10)-trien-17-one-16,16-d2,3-hydroxy- is primarily used in research settings, particularly in studies related to hormonal therapies and the mechanisms of estrogen action. Its unique isotopic labeling allows for advanced analytical techniques, such as mass spectrometry, to trace its behavior in biological systems.

Formula: C₁₈H₂₀D₂O₂

Synonyms:

• Estrone-16,16-D2

Estrone-16,16-d2

CAS: 56588-58-0

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 272.38

Ref: 3U-D5004

Estrone D2 (16,16-D2)

Controlled Product

CAS: 56588-58-0

Formula: C₁₈H₂H₂₀O₂

Color and Shape: Neat

Molecular weight: 272.38

Ref: 04-C13213232

Estrone-d2

Controlled Product

CAS: 56588-58-0

Applications Isotope labelled Estrone (E889050), which is a metabolite of 17β-Estradiol (E888000). During the metabolism, it is in rapid equilibrium with Estriol (E888960) and 17β-Estradiol (E888000) (1). Causes the feminization of male fish at human and animal waste sites (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Both, D. et al.: Anal. Prof. Drug Subst. 1983 12 pp135-1892. Goodman-Gruen, D. et al.: J. Clin. Endocrinol. Metab. 1996 Aug;81(8):2999-3003.

Formula: C₁₈₂H₂H₂₀O₂

Color and Shape: Off-White

Molecular weight: 272.38

Ref: TR-E889051

Estrone-d2

CAS: 56588-58-0

Estrone-d2 is a deuterated compound of Estrone. Estrone has a CAS number of 53-16-7. Estrone is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

Formula: C₁₈H₂₀D₂O₂

Color and Shape: Solid

Molecular weight: 272.38

Ref: TM-TMIJ-0313

Estrone-d2

Controlled Product

CAS: 56588-58-0

Estrone-d2 is an isotopically labeled estrogen that is used in analytical methods to highlight and analyze the presence of estrogens. Estrone-d2 is a synthetic form of estrone that contains two deuterium atoms and one carbon-18 atom. This compound can be used as an alternative to natural estrogens, which can interfere with the analytical method. The major use of this compound is to validate analytical methods for the detection of estrogens in various matrices. Estrone-d2 has been shown to be effective at recovering estrone from drinking water samples, although it does not recover other compounds such as ethinylestradiol or mestranol.

Formula: C₁₈H₂₂O₂

Purity: Min. 95%

Molecular weight: 272.4 g/mol

Ref: 3D-GCA58858