CAS 566-48-3

Formestane

Description:

Formestane, with the CAS number 566-48-3, is a synthetic steroid and an aromatase inhibitor primarily used in the treatment of hormone-dependent breast cancer. It functions by inhibiting the aromatase enzyme, which is responsible for converting androgens into estrogens, thereby reducing estrogen levels in the body. This mechanism is particularly beneficial in postmenopausal women, where estrogen can promote the growth of certain types of breast tumors. Formestane is characterized by its chemical structure, which includes a 4-hydroxyandrost-4-ene backbone, and it is typically administered via intramuscular injection. The substance has a relatively low solubility in water but is soluble in organic solvents, which is important for its formulation in pharmaceutical preparations. Side effects may include hot flashes, fatigue, and potential impacts on bone density due to lowered estrogen levels. Overall, Formestane plays a significant role in endocrine therapy for breast cancer, particularly in cases where estrogen plays a critical role in tumor growth.

Formula: C₁₉H₂₆O₃

InChI: InChI=1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

InChI key: InChIKey=OSVMTWJCGUFAOD-KZQROQTASA-N

SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)C(=O)CC4)[H])(CCC1=C(O)C(=O)CC2)[H])[H]

Synonyms:

• (8Xi,9Xi,14Xi)-4-Methylandrost-4-Ene-3,17-Dione
• 4-Had
• 4-Hydroxy-4-androstenedione
• 4-Hydroxyandrost-4-Ene-3,17-Dione
• 4-Hydroxyandrostene-3,17-dione
• 4-Hydroxyandrostenedione
• 4-Oha
• Androst-4-ene-3,17-dione, 4-hydroxy-
• B, Aromatase inhibitor
• Cgp 32349
• Crc 82/01
• Formestane
• Lentaron

Formestane

CAS: 566-48-3

Formula: C₁₉H₂₆O₃

Purity: ≥ 98.0%

Color and Shape: White powder

Molecular weight: 302.41

Ref: 7W-GP6256

Formestane

CAS: 566-48-3

Formula: C₁₉H₂₆O₃

Molecular weight: 302.42

Ref: 4Z-F-161

Formestane

Controlled Product

CAS: 566-48-3

Formula: C₁₉H₂₆O₃

Color and Shape: Neat

Molecular weight: 302.41

Ref: 86-MM0389.00

Formestane

Controlled Product

CAS: 566-48-3

Applications An antitumor drug. An aromatase inhibitor.
References Brodie, A.M. and Njar, V.C.: Steroids, 65, 171 (2000), Lonning, P.E., et al.: J. Steroid Biochem, 77, 39 (2001)

Formula: C₁₉H₂₆O₃

Color and Shape: Neat

Molecular weight: 302.41

Ref: TR-F692250

Formestane

Controlled Product

CAS: 566-48-3

Inhibitor of estrogen synthase

Formula: C₁₉H₂₆O₃

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 302.41 g/mol

Ref: 3D-FF23546