CAS 566-76-7

16α-Hydroxyestrone

Description:

16α-Hydroxyestrone is a naturally occurring estrogen and a metabolite of estrone, classified under the category of steroid hormones. Its chemical structure features a hydroxyl group (-OH) at the 16α position of the estrone backbone, which contributes to its biological activity. This compound is primarily involved in the metabolism of estrogens and has been studied for its potential role in various physiological processes, including reproductive health and bone density regulation. It exhibits estrogenic activity, influencing the growth and function of estrogen-sensitive tissues. Additionally, 16α-Hydroxyestrone has been investigated for its implications in hormone-related cancers, particularly breast cancer, due to its estrogenic effects. The substance is typically found in low concentrations in human tissues and biological fluids, and its levels can be influenced by factors such as age, hormonal status, and environmental exposures. As a chemical entity, it is characterized by its specific molecular formula and weight, and it is often analyzed in research settings to understand its pharmacological and toxicological properties.

Formula: C₁₈H₂₂O₃

InChI: InChI=1S/C18H22O3/c1-18-7-6-13-12-5-3-11(19)8-10(12)2-4-14(13)15(18)9-16(20)17(18)21/h3,5,8,13-16,19-20H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,18+/m1/s1

InChI key: InChIKey=WPOCIZJTELRQMF-QFXBJFAPSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(C[C@@H](O)C2=O)[H]

Synonyms:

• 3,16α-Dihydroxy-1,3,5(10)-estratrien-17-one
• 16α-Hydroxyestrone
• Estra-1,3,5(10)-trien-17-one, 3,16-dihydroxy-, (16α)-
• (16α)-3,16-Dihydroxyestra-1,3,5(10)-trien-17-one
• Estra-1,3,5(10)-trien-17-one, 3,16α-dihydroxy-

1,3,5[10]-Estratriene-3,16α-diol-17-one

CAS: 566-76-7

Formula: C₁₈H₂₂O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 286.3655

Ref: IN-DA00EBMG

Estriol EP Impurity H

CAS: 566-76-7

Formula: C₁₈H₂₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 286.37

Ref: 4Z-E-3513

16α-Hydroxyestrone

CAS: 566-76-7

16α-Hydroxyestrone

Purity: ≥95%

Molecular weight: 286.37g/mol

Ref: 54-OR1036437

3,16α-Dihydroxyestra-1,3,5(10)-trien-17-one (16α-Hydroxyestrone)

CAS: 566-76-7

Color and Shape: Neat

Ref: 86-MM0130.21

16α-Hydroxy Estrone

CAS: 566-76-7

Impurity Estriol EP Impurity H
Applications 16α-Hydroxy Estrone (Estriol EP Impurity H) is a major metabolite of Estradiol.
References Fishman, H.G, et al.: Biochemistry, 8, 4304 (1969), Ryan, Sugar, J., et al.: J. Clin. Endocrinol. Metab., 50, 137 (1980), Numazawa, M., et al.: Steroids, 38, 149 (1981), Travis, R., et al.: Breast Cancer Res., 5, 239 (2003),

Formula: C₁₈H₂₂O₃

Color and Shape: White To Beige

Molecular weight: 286.37

Ref: TR-H941900

16a-Hydroxy estrone

Controlled Product

CAS: 566-76-7

16a-Hydroxy estrone is a metabolite of estradiol that has been shown to be associated with an increased risk of breast cancer in women. 16a-Hydroxy estrone can be found in human wastewater and maternal blood, indicating that it may be present in the environment. The genotoxic activity of 16a-hydroxy estrone has been demonstrated by its ability to inhibit DNA synthesis and cellular transformation. It also inhibits the growth of cancer cells and reduces the disease activity of breast cancer. 16a-Hydroxy estrone has shown biological properties that are estrogenic, which may contribute to its carcinogenic activity.

Formula: C₁₈H₂₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 286.37 g/mol

Ref: 3D-FH59537

Estriol EP Impurity H

CAS: 566-76-7

Formula: C₁₈H₂₂O₃

Molecular weight: 286.4

Ref: ST-EA-CP-E28008