CAS 566-97-2

Δ8-Cholestenol

Description:

Δ8-Cholestenol, also known as 8-cholestenol, is a sterol compound that plays a significant role in various biological processes. It is a derivative of cholesterol, characterized by the presence of a double bond between the eighth and ninth carbon atoms in its steroid structure. This structural modification influences its physical and chemical properties, including its solubility and membrane fluidity. Δ8-Cholestenol is typically found in animal tissues and is involved in the biosynthesis of other sterols and steroid hormones. It can also serve as a precursor in the synthesis of vitamin D. The compound is generally stable under standard conditions but may undergo oxidation or isomerization under certain circumstances. Its presence can be detected and quantified using techniques such as gas chromatography and mass spectrometry. In terms of biological activity, Δ8-Cholestenol has been studied for its potential roles in cellular signaling and its implications in various health conditions, including cardiovascular diseases and metabolic disorders.

Formula: C₂₇H₄₆O

InChI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1

InChI key: InChIKey=QETLKNDKQOXZRP-XTGBIJOFSA-N

SMILES: C[C@@]12[C@](C3=C([C@]4(C)[C@@](CC3)(C[C@@H](O)CC4)[H])CC1)(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]

Synonyms:

• (3β,5α)-Cholest-8-en-3-ol
• 3β-Hydroxy-5α-cholest-8(9)-ene
• 5alpha-Cholest-8(9)-en-3beta-ol
• 5α-Cholest-8-en-3β-ol
• Cholest-8-en-3-ol, (3beta,5alpha)-
• Cholest-8-en-3-ol, (3β,5α)-
• Dihydrozymosterol
• Zymostenol
• delta(8)-Cholestenol
• Δ⁸-Cholestenol

Zymostenol

CAS: 566-97-2

Zymostenol (5a-Cholest-8-en-3b-ol) is a RORγ agonist with an EC50 of 1 μM.Zymostenol is a late stage precursor of cholesterol biosynthesis.

Formula: C₂₇H₄₆O

Purity: 98%

Color and Shape: Solid

Molecular weight: 386.65

Ref: TM-T35321

Zymostenol

Controlled Product

CAS: 566-97-2

Applications Zymostenol, is the derivative of Zymosterol (Z701520), which is an sterol intermediate in the biosynthesis of cholesterol (C432501).
References Roland, E.D., et al.: J. Am. Chem. Soc., 111, 278 (1989); Echevarria, F., et al.: J. Biol. Chem., 265, 8484 (1990); Baranovskii, A.V., et al.: Russian. J. Bioorg. Chem., 28, 250 (2002); Schoenheimer, et al.: J. Biol. Chem., 105, 355 (1934);

Formula: C₂₇H₄₆O

Color and Shape: Neat

Molecular weight: 386.65

Ref: TR-Z701530