CAS 56605-16-4

Spiromustine

Description:

Spiromustine, with the CAS number 56605-16-4, is a synthetic alkylating agent that belongs to the class of nitrogen mustards. It is primarily characterized by its unique structure, which includes a spirocyclic moiety that contributes to its biological activity. Spiromustine exhibits antitumor properties and has been investigated for its potential use in cancer therapy, particularly in the treatment of various malignancies. The compound functions by forming covalent bonds with DNA, leading to cross-linking and subsequent disruption of DNA replication and transcription, ultimately inducing apoptosis in cancer cells. Its pharmacokinetics and toxicity profile are important considerations in its therapeutic application, as with many chemotherapeutic agents. Additionally, the compound's solubility, stability, and reactivity are critical factors that influence its efficacy and safety in clinical settings. Ongoing research continues to explore its potential benefits and limitations in oncology.

Formula: C₁₄H₂₃Cl₂N₃O₂

InChI: InChI=1/C14H23Cl2N3O2/c15-6-8-18(9-7-16)10-11-19-12(20)14(17-13(19)21)4-2-1-3-5-14/h1-11H2,(H,17,21)

InChI key: InChIKey=QNKJFXARIMSDBR-UHFFFAOYSA-N

SMILES: O=C1C2(NC(=O)N1CCN(CCCl)CCCl)CCCCC2

Synonyms:

• 1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[2-[bis(2-chloroethyl)amino]ethyl]-
• 3-[2-[Bis(2-chloroethyl)amino]ethyl]-5,5-pentamethylenehydantoin
• 3-{2-[Bis(2-Chloroethyl)Amino]Ethyl}-1,3-Diazaspiro[4.5]Decane-2,4-Dione
• NSC 172112
• NSC 268497
• Nci 172112
• SHM
• Spirohydantoin mustard
• Spiromustine
• NSC268497
• Spiromustard
• Spirohydantoin masturd
• NCI172112
• 3-[2-[bis(2-chloroethyl)amino]ethyl]-1,3-diazaspiro[4.5]decane-2,4-quinone

NCI172112

CAS: 56605-16-4

NCI172112 is a human immunoglobulin that has been genetically engineered to be resistant to proteolytic degradation by serine proteases. It binds to the surface of cancer cells and blocks the growth of tumor cells in culture. NCI172112 has also been shown to reduce cardiac hypertrophy in animals, which may be due to its ability to decrease fatty acid levels in the heart. The covalent linkage between NCI172112 and human serum albumin prevents it from being easily degraded by enzymes in the body. NCI172112 has also been shown to have a diagnostic effect on cancerous tissue and can be used as a treatment for cancer.

Formula: C₁₄H₂₃Cl₂N₃O₂

Purity: Min. 95%

Molecular weight: 336.3 g/mol

Ref: 3D-GCA60516

NCI172112

CAS: 56605-16-4

NCI172112 is is used to develop antitumor agents effective against CNS tumors.

Formula: C₁₄H₂₃Cl₂N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 336.26

Ref: TM-T12195