CAS 56621-48-8

N-(4-Hydroxyphenyl)piperazine

Description:

N-(4-Hydroxyphenyl)piperazine, with the CAS number 56621-48-8, is an organic compound characterized by its piperazine core, which is a six-membered ring containing two nitrogen atoms. This compound features a hydroxyl group (-OH) attached to a phenyl ring at the para position, contributing to its chemical properties. It is typically a white to off-white solid and is soluble in polar solvents such as water and alcohols, owing to the presence of the hydroxyl group. The compound exhibits potential biological activity, making it of interest in medicinal chemistry, particularly in the development of pharmaceuticals. Its structure allows for interactions with various biological targets, which may include neurotransmitter receptors. Additionally, N-(4-Hydroxyphenyl)piperazine can participate in various chemical reactions, including substitutions and coupling reactions, making it a versatile intermediate in organic synthesis. Safety and handling precautions should be observed, as with any chemical substance, due to potential toxicity or reactivity.

Formula: C₁₀H₁₄N₂O

InChI: InChI=1/C10H14N2O/c13-10-3-1-9(2-4-10)12-7-5-11-6-8-12/h1-4,11,13H,5-8H2

InChI key: InChIKey=GPEOAEVZTOQXLG-UHFFFAOYSA-N

SMILES: OC1=CC=C(C=C1)N2CCNCC2

Synonyms:

• 1-(4-Hydroxyphenyl)piperazine
• 4-(1-Piperazino)phenol
• 4-(1-Piperazinyl)phenol
• 4-(4-Hydroxyphenyl)piperazine
• 4-(Piperazin-1-Yl)Phenol
• 4-Hydroxy Phenyl Piperazine
• 4-Piperazinophenol
• Phenol, 4-(1-piperazinyl)-
• N-(4-Hydroxyphenyl)piperazine
• RARECHEM AH CK 0119
• 1-(4-HYDROXYPHENYL)PIPERAZINE HYDROCHLORIDE
• p-(1-piperazinyl)phenol
• 1-(4-HYDROXYPHENYL)PROPERAZINE
• 1-(4-Hydroxyphenyl)piperazine 98%
• Phenol, 4-(1-piperazinyl)-(9CI)
• LABOTEST-BB LT00233198
• 4-(1-Piperazino)phenol,98%
• SALOR-INT L497754-1EA
• 4-(1-PIPERAZINO)PHENOL 98%

4-(1-Piperazinyl)phenol, 95%

CAS: 56621-48-8

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₀H₁₄N₂O

Purity: 95%

Color and Shape: Powder, Pale brown to brown or pink

Molecular weight: 178.24

Ref: 02-B20122

4-(Piperazin-1-yl)phenol

CAS: 56621-48-8

Formula: C₁₀H₁₄N₂O

Purity: 97%

Color and Shape: Solid

Molecular weight: 178.2310

Ref: IN-DA003CZW

1-(4-Hydroxyphenyl)piperazine

CAS: 56621-48-8

Formula: C₁₀H₁₄N₂O

Purity: >98.0%(GC)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 178.24

Ref: 3B-H0891

4-(Piperazin-1-yl)phenol

CAS: 56621-48-8

4-(Piperazin-1-yl)phenol

Formula: C₁₀H₁₄N₂O

Purity: 98%

Color and Shape: beige solid

Molecular weight: 178.23g/mol

Ref: 54-OR6840

Posaconazole Impurity 128

CAS: 56621-48-8

Formula: C₁₀H₁₄N₂O

Molecular weight: 178.24

Ref: 4Z-P-38161

Posaconazole Impurity 96

CAS: 56621-48-8

Formula: C₁₀H₁₄N₂O

Molecular weight: 178.24

Ref: ST-EA-CP-P24074

1-(4-Hydroxyphenyl)-piperazine

CAS: 56621-48-8

Formula: C₁₀H₁₄N₂O

Purity: 97%

Color and Shape: Crystalline

Molecular weight: 178.235

Ref: 10-F009797

1-(4-Hydroxyphenyl)piperazine

Controlled Product

CAS: 56621-48-8

Applications 1-(4-Hydroxyphenyl)piperazine

Formula: C₁₀H₁₄N₂O

Color and Shape: Neat

Molecular weight: 178.23

Ref: TR-H952888

1-(4-Hydroxyphenyl)piperazine

CAS: 56621-48-8

1-(4-Hydroxyphenyl)piperazine (HPP) is a drug that is metabolized by the liver cytochrome P450 system. It inhibits the oxidation of coumarin derivatives and facilitates their coupling with hydroxyl groups, which results in the formation of 1-hydroxy-2-oxo-3-(4-hydroxyphenyl)piperazines. HPP has been shown to inhibit hepatic cytochrome P450 in humans, as well as mouse liver microsomes. This inhibition can be reversed by adding chemical inhibitors such as phenobarbital or aminopyrine. HPP also catalyzes glutaminyl cyclase to form glutaminyl amino acids, and is involved in the production of heme, which may be due to its ferroelectric properties. HPP has been shown to be effective against spermatogenesis in male rats, and it was found that HPP was excreted from human

Formula: C₁₀H₁₄N₂O

Purity: Min. 95%

Molecular weight: 178.23 g/mol

Ref: 3D-FH75439