CAS 56632-39-4

2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-

Description:

2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl- (CAS 56632-39-4) is a chemical compound characterized by its indole structure, which is a bicyclic compound consisting of a benzene ring fused to a pyrrole ring. This specific compound features a methyl group at the 7-position and two hydroxyphenyl groups at the 3-position, contributing to its unique properties. It is typically classified as an indole derivative and may exhibit biological activity, potentially serving as a scaffold for pharmaceutical development. The presence of hydroxyl groups suggests that it may engage in hydrogen bonding, influencing its solubility and reactivity. Additionally, the compound's structure may allow for various substitution reactions, making it of interest in synthetic organic chemistry. Its potential applications could span across medicinal chemistry, where it may be investigated for therapeutic effects, as well as in materials science due to its structural characteristics. Overall, the compound's unique features make it a subject of interest in various fields of research.

Formula: C₂₁H₁₇NO₃

BHPI

CAS: 56632-39-4

Formula: C₂₁H₁₇NO₃

Purity: %

Color and Shape: Solid

Molecular weight: 331.3646

Ref: IN-DA00ECFD

BHPI

Controlled Product

CAS: 56632-39-4

Applications BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial and ovarian cancer cell lines.
References Andruska, N. et al.: PNAC. Sci. U.S.A., 112, 4737 (2015);

Formula: C₂₁H₁₇NO₃

Color and Shape: Neat

Molecular weight: 331.37

Ref: TR-B372000

BHPI

CAS: 56632-39-4

BHPI is a non-selective cation that blocks the amp-activated protein kinase (AMPK) and thereby induces necrotic cell death. BHPI also inhibits the activity of fatty acid synthase, which is an enzyme involved in lipid synthesis. This inhibition results in the accumulation of lipids inside the cells, leading to necrosis. BHPI has been shown to inhibit cancer cell growth by inhibiting protein synthesis and inducing apoptosis. It also inhibits estrogen receptor-mediated signaling pathways, which prevents estrogen from binding to its receptors, thereby blocking the response pathway.

Formula: C₂₁H₁₇NO₃

Purity: Min. 95%

Molecular weight: 331.36 g/mol

Ref: 3D-GCA63239

BHPI

CAS: 56632-39-4

BHPI is a potent ERα inhibitor, activating UPR and blocking protein synthesis with an IC50 value. It depletes EnR Ca(2+) via PLCγ in ERα(+) cancer cells.

Formula: C₂₁H₁₇NO₃

Color and Shape: Solid

Molecular weight: 331.36

Ref: TM-T14553