CAS 566939-85-3

Orteronel

Description:

Orteronel, also known by its chemical name, is a selective inhibitor of the enzyme 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3), which plays a crucial role in the biosynthesis of testosterone. This compound is primarily investigated for its potential therapeutic applications in treating conditions related to androgen excess, such as prostate cancer and benign prostatic hyperplasia. Orteronel exhibits a unique mechanism of action by specifically targeting the conversion of androstenedione to testosterone, thereby reducing testosterone levels in the body. Its pharmacological profile suggests a favorable safety and efficacy balance, making it a candidate for further clinical evaluation. The substance is characterized by its specific molecular structure, which contributes to its selectivity and potency as an inhibitor. Additionally, studies have indicated that Orteronel may have a favorable pharmacokinetic profile, allowing for effective dosing regimens. As research continues, its full therapeutic potential and side effect profile will be better understood, contributing to advancements in androgen-related therapies.

Formula: C₁₈H₁₇N₃O₂

InChI: InChI=1S/C18H17N3O2/c1-19-17(22)14-3-2-13-9-15(5-4-12(13)8-14)18(23)6-7-21-11-20-10-16(18)21/h2-5,8-11,23H,6-7H2,1H3,(H,19,22)/t18-/m0/s1

InChI key: InChIKey=OZPFIJIOIVJZMN-SFHVURJKSA-N

SMILES: O[C@]1(C=2N(CC1)C=NC2)C3=CC4=C(C=C3)C=C(C(NC)=O)C=C4

Synonyms:

• 6-[(7S)-6,7-Dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide
• 6-[(7S)-7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide
• TAK 700
• 2-Naphthalenecarboxamide, 6-[(7S)-6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-
• Orteronel

6-[(7S)-7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-2-naphthalenecarboxamide

CAS: 566939-85-3

Formula: C₁₈H₁₇N₃O₂

Purity: 99.70%

Color and Shape: Solid

Molecular weight: 307.3465

Ref: IN-DA00ECEF

(S)-6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide

CAS: 566939-85-3

(S)-6-(7-Hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide

Purity: 99%

Molecular weight: 307.35g/mol

Ref: 54-OR1066058

Orteronel

CAS: 566939-85-3

Orteronel ((S)-Orteronel)(TAK-700) was selected as a candidate for clinical evaluation.

Formula: C₁₈H₁₇N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 307.35

Ref: TM-T6051

Orteronel

Controlled Product

CAS: 566939-85-3

Formula: C₁₈H₁₇N₃O₂

Color and Shape: Neat

Molecular weight: 307.346

Ref: TR-O697600

CYP17A1 Inhibitor II, TAK-700

CAS: 566939-85-3

TAK-700 is a CYP17A1 inhibitor that prevents the production of androgens by inhibiting the activity of cytochrome P450, which is known to be involved in the conversion of androstenedione to testosterone. TAK-700 has been shown to inhibit the growth of prostate cancer cells in vitro. It also has anti-inflammatory properties and can be used for the treatment of infectious diseases.

Formula: C₁₈H₁₇N₃O₂

Purity: Min. 95%

Molecular weight: 307.35 g/mol

Ref: 3D-RXA93985