CAS 567-03-3

Tetrahydrodeoxycorticosterone

Description:

Tetrahydrodeoxycorticosterone (THDOC) is a steroid hormone that belongs to the class of corticosteroids. It is a metabolite of deoxycorticosterone and is primarily produced in the adrenal glands. THDOC plays a role in the regulation of electrolyte balance and has been implicated in various physiological processes, including the modulation of blood pressure and stress response. The substance is characterized by its four-ring steroid structure, which is typical of corticosteroids, and it exhibits both mineralocorticoid and glucocorticoid activity, albeit to a lesser extent than other corticosteroids like cortisol. THDOC is known to interact with mineralocorticoid receptors, influencing sodium and potassium balance in the body. Additionally, it has been studied for its potential neuroactive properties, as it can cross the blood-brain barrier and may affect mood and behavior. Due to its hormonal nature, THDOC is subject to regulation in various contexts, particularly in sports and medicine, where its use may be monitored for performance enhancement or therapeutic purposes.

Formula: C₂₁H₃₄O₃

InChI: InChI=1S/C21H34O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h13-18,22-23H,3-12H2,1-2H3/t13-,14-,15+,16+,17+,18-,20+,21+/m1/s1

InChI key: InChIKey=CYKYBWRSLLXBOW-DATPGIFZSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@H]2C(CO)=O)[H]

Synonyms:

• (3Alpha,5Alpha)-3,21-Dihydroxypregnan-20-One
• (3Alpha,5Beta)-3,21-Dihydroxypregnan-20-One
• (3α,5β)-3,21-Dihydroxypregnan-20-one
• 21-Hydroxypregnanolone
• 3alpha,21-Dihydroxy-5beta-pregnan-20-one
• 3α,21-Dihydroxy-5β-pregnan-20-one
• 3α,5β-Tetrahydrodeoxycorticosterone
• 5β-Pregnan-20-one, 3α,21-dihydroxy-
• 5β-Pregnan-3α,21-diol-20-one
• Corticosterone, 11-deoxytetrahydro-
• Corticosterone, deoxytetrahydro-
• Deoxytetrahydrocorticosterone
• Pregnan-20-one, 3,21-dihydroxy-, (3α,5β)-
• Tetrahydro DOC
• Tetrahydro-11-deoxycorticosterone

Tetrahydro 11-Deoxycorticosterone

Controlled Product

CAS: 567-03-3

Applications Tetrahydro 11-Deoxycorticosterone is a metabolite of 11-Deoxycorticosterone (DOC) (D232590).
References Fedele, E., et al.: J. Neurochem., 75, 782 (2000), Adkins, C., et al.: J. Biol. Chem., 276, 38934 (2001), Erceg, S., et al.: Brain Res., 1036, 115 (2005),

Formula: C₂₁H₃₄O₃

Color and Shape: White To Off-White

Molecular weight: 334.49

Ref: TR-T293270

Tetrahydro 11-deoxycorticosterone

Controlled Product

CAS: 567-03-3

Tetrahydro 11-deoxycorticosterone is a model system that is used to study the effects of steroids on the nervous system. It has been shown to bind to the α1 subunit of receptors and can also block cation channels. Tetrahydro 11-deoxycorticosterone may be useful in treating diseases such as Alzheimer's disease, epilepsy, and schizophrenia. This drug has also been shown to have a positive effect on body mass index in women.

Formula: C₂₁H₃₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 334.49 g/mol

Ref: 3D-FT28081

Tetrahydro 11-Deoxycorticosterone-D5

Controlled Product

CAS: 567-03-3

Formula: C₂₁D₅H₂₉O₃

Color and Shape: Neat

Molecular weight: 339.524

Ref: TR-T293272

Tetrahydrodeoxycorticosterone

CAS: 567-03-3

Tetrahydrodeoxycorticosterone(Tetrahydro-11-deoxycorticosterone) is a potent GABAA receptor orthosteric modulator (PAM) with neuroprotective activity that selectively inhibits neurosteroid-mediated enhancement of GABA-induced currents at the GABAA receptor, and can be used in the study of neurological disorders.

Formula: C₂₁H₃₄O₃

Purity: 99.40%

Color and Shape: Solid

Molecular weight: 334.49

Ref: TM-T37725