CAS 56845-87-5

(3β,25R)-3-Hydroxycholest-5-en-26-oic acid

Description:

(3β,25R)-3-Hydroxycholest-5-en-26-oic acid, also known as 3-hydroxycholestenoic acid, is a sterol derivative characterized by its hydroxyl group at the 3-position and a carboxylic acid functional group at the 26-position of the cholesterol backbone. This compound is part of the steroid family and exhibits a complex structure that includes multiple rings and a double bond, contributing to its biological activity. It is typically found in various biological systems and is involved in metabolic pathways related to cholesterol and steroid hormone synthesis. The presence of the hydroxyl and carboxylic acid groups enhances its solubility in polar solvents, influencing its interactions within biological membranes and its role in cellular signaling. Additionally, this compound may have implications in research related to lipid metabolism and cardiovascular health. Its CAS number, 56845-87-5, is a unique identifier that facilitates its identification in scientific literature and databases.

Formula: C₂₇H₄₄O₃

InChI: InChI=1S/C27H44O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h8,17-18,20-24,28H,5-7,9-16H2,1-4H3,(H,29,30)/t17-,18-,20+,21+,22-,23+,24+,26+,27-/m1/s1

InChI key: InChIKey=WVXOMPRLWLXFAP-KQOPCUSDSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCC[C@H](C(O)=O)C)C)[H])[H]

Synonyms:

• (3β,25R)-3-Hydroxycholest-5-en-26-oic acid
• Cholest-5-en-26-oic acid, 3-hydroxy-, (3β,25R)-

5-Cholestene-26-oic acid-3β-ol

CAS: 56845-87-5

5-Cholestene-26-oic acid-3β-ol is a cholesterol catabolite [1] .

Formula: C₂₇H₄₄O₃

Color and Shape: Solid

Molecular weight: 416.64

Ref: TM-T75580

(3β,25R)-Hydroxy-5-cholestenoic Acid

Controlled Product

CAS: 56845-87-5

Formula: C₂₇H₄₄O₃

Color and Shape: Neat

Molecular weight: 416.637

Ref: TR-H917505

(3β,25R)-Hydroxy-5-cholestenoic acid

Controlled Product

CAS: 56845-87-5

The cholesterol 25-hydroxylase (CYP7A1) is an enzyme that catalyzes the conversion of cholesterol to bile acids and is a key regulatory enzyme in the biosynthesis of bile acids. Mutations in CYP7A1 have been associated with atherosclerotic cardiovascular disease. The human CYP7A1 gene encodes a protein which contains several transcription factor response elements, including those for Sp1 and AP-2. The CYP7A1 gene also contains binding sites for nuclear receptors, such as PPARα, which regulate its expression. This gene product is involved in cholesterol metabolism by converting it to bile acids and has shown to be regulated by PPARα.

Formula: C₂₇H₄₄O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 416.64 g/mol

Ref: 3D-GCA84587