CAS 5697-56-3

Carbenoxolone

Description:

Carbenoxolone is a synthetic compound derived from glycyrrhetinic acid, primarily known for its use in medicinal applications, particularly as an anti-inflammatory and ulcer-healing agent. It functions by inhibiting the enzyme 11β-hydroxysteroid dehydrogenase, which plays a crucial role in the metabolism of corticosteroids. This inhibition can lead to increased local concentrations of active glucocorticoids, enhancing its therapeutic effects. Carbenoxolone exhibits properties that may promote mucosal healing and reduce gastric acid secretion, making it beneficial in treating conditions like peptic ulcers and gastroesophageal reflux disease. The substance is typically administered in the form of its sodium salt, which enhances its solubility and bioavailability. While generally well-tolerated, potential side effects may include electrolyte imbalances and hypertension due to its mineralocorticoid-like effects. As with any pharmacological agent, its use should be monitored, particularly in patients with pre-existing conditions that may be exacerbated by corticosteroid activity. Overall, carbenoxolone represents a valuable therapeutic option in gastrointestinal medicine.

Formula: C₃₄H₅₂O₈

InChI: InChI=1/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6;;/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40);;/q;2*+1/p-2/t21-,23?,24-,27?,30+,31-,32-,33+,34+;;/m0../s1

InChI key: InChIKey=OBZHEBDUNPOCJG-WBXJDKIVSA-N

SMILES: C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](OC(CCC(O)=O)=O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@]4(C[C@](C(O)=O)(C)CC5)[H])[H]

Synonyms:

• (3Beta)-3-[(3-Carboxypropanoyl)Oxy]-11-Oxoolean-12-En-30-Oic Acid
• (3beta)-3-[(3-Carboxypropanoyl)oxy]-11-oxoolean-12-en-30-oic acid Carbenoxolone
• (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
• 3-(3-Carboxy-1-oxopropoxy)-11-oxo-olean-12-en-29-oic acid
• 3-O-(β-Carboxypropionyl)-11-oxo-18β-olean-12-en-30-oic acid
• 3β-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate
• 8Xi,10Xi,17Xi,18Xi)-3-[(3-Carboxypropanoyl)Oxy]-11-Oxoolean-12-En-30-Oic Acid
• Biogastrone
• Disodium (3Beta,5Xi,9Xi)-3-[(3-Carboxylatopropanoyl)Oxy]-11-Oxoolean-12-En-30-Oate
• Glycyrrhetinic Acid Hydrogen Succinate
• Glycyrrhetinic acid succinate
• Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3β,20β)-
• Olean-12-en-30-oic acid, 3β-hydroxy-11-oxo-, hydrogen succinate
• Olean-12-en-30-oic acid, 3β-hydroxy-11-oxo-, succinate
• CARBENOXOLONE
• 3-beta-(3-carboxypropionyloxy)-11-oxo-olean-12-en-30-oicacid
• bioral
• 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate
• 3-beta-hydroxy-11-oxo-olean-12-en-30-oicacihydrogensuccinate

Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-,(3b,20b)-

CAS: 5697-56-3

Formula: C₃₄H₅₀O₇

Purity: 97%

Color and Shape: Solid

Molecular weight: 570.7566

Ref: IN-DA00IA60

Carbenoxolone

CAS: 5697-56-3

Carbenoxolone

Purity: ≥98%

Molecular weight: 570.76g/mol

Ref: 54-BUP20157

Carbenoxolone-d4

CAS: 5697-56-3

Formula: C₃₄H₄₆D₄O₇

Color and Shape: White To Off-White Solid

Molecular weight: 574.79

Ref: 4Z-C-326002

Carbenoxolone

CAS: 5697-56-3

Carbenoxolone (Biogastrone) is an inhibitor of 11β-HSD and gap junction connexin channels.

Formula: C₃₄H₅₀O₇

Purity: 99.75%

Color and Shape: White Crystalline Powder

Molecular weight: 570.76

Ref: TM-T7732

Carbenoxolone

Controlled Product

CAS: 5697-56-3

Applications Carbenoxolone

Formula: C₃₄H₅₀O₇

Color and Shape: Neat

Molecular weight: 570.76

Ref: TR-C175903

(3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid

Controlled Product

CAS: 5697-56-3

1-Carboxy-2-[(2S,3R,4S)-1-carboxy-3-hydroxypropyl]-sn-glycero 3-phosphoethanolamine is a vaccine that is used to treat bowel disease and autoimmune diseases. It has been shown to induce the production of antibodies against melanoma antigen in mice. This drug also has an effect on metabolic disorders such as diabetes mellitus and obesity. 1-Carboxy-2-[(2S,3R,4S)-1-carboxy-3-hydroxypropyl]-sn-glycero 3-phosphoethanolamine is an ethylene diamine derivative with a hydroxyl group on the C2 position.

Formula: C₃₄H₅₀O₇

Purity: Min. 95%

Molecular weight: 570.76 g/mol

Ref: 3D-FC140637